Changes in urinary catecholamines and their metabolites in depressed patients treated with amitriptyline or imipramine.
Changes in urinary catecholamines and their metabolites in depressed patients treated with amitriptyline or imipramine.
复制标题
接受阿米替林或丙咪嗪治疗的抑郁症患者尿儿茶酚胺及其代谢物的变化。
DOI：
10.1016/0022-3956(87)90012-4
复制
发表时间：
1987
影响因子：
4.8
通讯作者：
Hanin,I
中科院分区：
文献类型：
--
作者：
Bowden,CL;Koslow,S;Maas,JW;Davis,J;Garver,DL;Hanin,I
本文观察了95例单相和双相抑郁症患者服用阿米替林（AMI）或丙咪嗪（IMI）后尿中儿茶酚胺及其代谢产物的变化。对于未按药物分开的整个组，所有代谢物（但不包括儿茶酚胺）的浓度均大幅降低。虽然儿茶酚胺和代谢物的变化是相似的大多数物质测定，有一些特定的药物和诊断组的差异。香草基扁桃酸（VMA）减少仅限于双相患者;间苯丙氨酸（M）减少仅限于单极患者。更大的M和3-甲氧基-4-羟基苯乙二醇（MHPG）减少与单极患者的反应相关，但与双相患者无关。在双相情感障碍患者中，反应者的去甲肾上腺素（NE）升高，而无反应的双相情感障碍患者则降低。结果表明，阻断去甲肾上腺素再摄取的有效性可能对双相患者的恢复比单极患者更重要。研究电池的胺物质可能有助于更多的信息，我们了解抗抑郁药物对胺能系统的影响比单独分析MHPG。
The effects of treatment with amitriptyline (AMI) or imipramine (IMI) on changes in catecholamines and their metabolites in urine were studied in 95 unipolar and bipolar depressed patients. For the entire group, not separated by drug, substantial reduction in concentrations of all metabolites, but not catecholamines, occurred. Although catecholamine and metabolite change was similar for most substances assayed, there were some specific drug and diagnostic group differences. Vanillylmandelic acid (VMA) reduction was limited to bipolar patients; metanephrine (M) reduction to unipolar patients. Greater M and 3-methoxy-4-hydroxyphenylglycol (MHPG) reduction were associated with response in unipolar, but not bipolar patients. In bipolar, but not unipolar patients, norepinephrine (NE) rose in responders in contrast to reductions among nonresponding bipolar patients. The results suggest that effectiveness of blockade of reuptake of norepinephrine may be relatively more important for recovery in bipolar than in unipolar patients. Study of a battery of amine substances may contribute more information to our understanding of antidepressant drug effects on aminergic systems than analyses of MHPG alone.