Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin.
Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin.
复制标题
鼓室内滴注庆大霉素单侧前庭传入神经阻滞后主观视觉水平的恢复。
DOI：
10.3233/ves-2006-161-207
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
S. Iwasaki
中科院分区：
文献类型：
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作者：
Yoshinari Takai;T. Murofushi;M. Ushio;S. Iwasaki
本文研究了鼓室内注入庆大霉素对单侧前庭传入阻滞后主观视水平（SVH）恢复的时间过程。6例接受鼓室内庆大霉素滴注治疗梅尼埃病的患者（1例男性和5例女性，年龄32 - 69岁）入组本研究。为了比较，还测量了23名健康受试者（12名男性和11名女性，23至48岁）的SVH。健康受试者中SVH的平均值± SD为0.0 ± 1.1 °。6例患者在治疗后早期均表现出明显的SVH向注射侧向下偏移。虽然一名患者在注射后25天显示SVH恢复到正常范围，但其他患者需要更多的时间恢复。3例患者1年后未恢复至正常范围。另一方面，在完全黑暗中使用红外线CCD照相机观察到的自发性眼球震颤在35天（中位数）后消失。治疗前前庭诱发肌源性电位正常者，SVH恢复有延迟的趋势。本文讨论了SVH恢复时间长于自发性眼球震颤消失时间的原因。
The time course of the recovery of subjective visual horizontal (SVH) after unilateral vestibular deafferentation by intratympanic instillation of gentamicin was studied. Six patients who underwent intratympanic gentamicin instillation therapy for Meniere's disease (1 man and 5 women, 32 to 69 years of age) were enrolled in this study. For comparison, SVH in 23 healthy subjects (12 men and 11 woman, 23 to 48 years of age) was also measured. The mean +/- SD of SVH in healthy subjects was 0.0 +/- 1.1 deg. All of the 6 patients showed significantly deviated SVH toward the injected side-down at the early stage after the therapy. Although one patient showed recovery of SVH to the normal range 25 days after the injection, the other patients required more time for recovery. Three patients did not show recovery to the normal range after 1 year. On the other hand, spontaneous nystagmus observed using an infrared CCD camera in total dark disappeared after 35 days (median). Patients who had normal vestibular evoked myogenic potentials before the therapy showed a tendency of delay of recovery of SVH. The reasons why the recovery of SVH took longer than the disappearance of spontaneous nystagmus are discussed in this report.
梅尼埃病。
DOI：
10.1007/bf00168023
发表时间：
1995
期刊：
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
影响因子：
--
作者：
Merchant,SN;Rauch,SD;NadolJr,JB
通讯作者：
NadolJr,JB