Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging
Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging
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DOI：
10.1007/bf02985059
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发表时间：
2005-10
影响因子：
2.6
通讯作者：
N. Kubo;Songji Zhao;Y. Fujiki;A. Kinda;N. Motomura;C. Katoh;T. Shiga;H. Kawashima;Y. Kuge;N. Tamaki
中科院分区：
文献类型：
--
作者：
N. Kubo;Songji Zhao;Y. Fujiki;A. Kinda;N. Motomura;C. Katoh;T. Shiga;H. Kawashima;Y. Kuge;N. Tamaki
目的小动物影像学近年来已成为基础核医学的研究热点。我们设计并制作了一个小动物SPECT成像系统，该系统采用半导体摄像机和新设计的准直器。我们评估该系统的性能为小物体imaging.MethodsWe采用了MGC1500（Acrorad公司）。包括CdTe半导体的照相机。像素尺寸为1.4mm/像素。我们设计并制作了一个平行孔准直器与20毫米孔长。我们的SPECT系统包括一个半导体摄像机与主题保持器设置在一个由计算机控制的电动旋转台。我们比较了这个系统与传统的小动物SPECT系统，包括SPECT-2000H扫描仪与四个愤怒型相机和针孔准直器。对含有不同浓度99mTc的饼图体模进行了散点估计的计数率线性评价。测量了99mTc SPECT线源沿着散射方向的半高宽。使用长35 mm、内径32 mm的泛源体模检查系统体积灵敏度。此外，anin vivomyocytes灌注SPECT研究与大鼠。结果关于能量分辨率，半导体相机（5. 6%）是优于传统的愤怒型相机（9. 8%）上级。在计数率线性评价中，本系统SPECT值的回归直线为：y = 0.09x +0.031（r2 = 0.999），常规系统为：y = 0.018 *+0.060（r2 = 0.997）。因此，使用半导体照相机的散射计数小于使用传统照相机的散射计数。本系统和传统系统的半高宽分别为2.9 ± 0.1和2.0 ± 0.1mm。此外，我们的系统的系统体积灵敏度[0.51 kcps/（MBq/ml）/cm]优于传统系统的系统体积灵敏度[0.44 kcps/（MBq/ml）/cm]。我们的系统提供了清晰的图像，大鼠心肌，足以实际使用在小动物imaging. ConclusionsOur SPECT系统，利用半导体相机，允许高定量分析凭借其低散射辐射和高灵敏度。因此，该系统可能有助于小动物的分子成像和基础医学研究。关键词：半导体探测器，小动物成像，单光子发射计算机断层扫描
ObjectivesSmall animal imaging has recently been focused on basic nuclear medicine. We have designed and built a small animal SPECT imaging system using a semiconductor camera and a newly designed collimator. We assess the performance of this system for small object imaging.MethodsWe employed an MGC1500 (Acrorad Co.) camera including a CdTe semiconductor. The pixel size was 1.4 mm/pixel. We designed and produced a parallel-hole collimator with 20-mm hole length. Our SPECT system consisted of a semiconductor camera with the subject holder set on an electric rotating stage controlled by a computer. We compared this system with a conventional small animal SPECT system comprising a SPECT-2000H scanner with four Anger type cameras and pinhole collimators. The count rate linearity for estimation of the scatter was evaluated for a pie-chart phantom containing different concentrations of99mTc. We measured the FWHM of the99mTc SPECT line source along with scatter. The system volume sensitivity was examined using a flood source phantom which was 35 mm long with a 32-mm inside diameter. Additionally, anin vivomyocardial perfusion SPECT study was performed with a rat.ResultsWith regards to energy resolution, the semiconductor camera (5.6%) was superior to the conventional Anger type camera (9.8%). In the count rate linearity evaluation, the regression lines of the SPECT values werey =0.0 9x+0.031 (r2= 0.999) for our system andy =0.018* + 0.060 (r2= 0.997) for the conventional system. Thus, the scatter count using the semiconductor camera was less than that using the conventional camera. FWHMs of our system and the conventional system were 2.9 ± 0.1 and 2.0 ± 0.1 mm, respectively. Moreover, the system volume sensitivity of our system [0.51 kcps/(MBq/ ml)/cm] was superior to that of the conventional system [0.44 kcps/(MBq/m/)/cm]. Our system provided clear images of the rat myocardium, sufficient for practical use in small animal imaging.ConclusionsOur SPECT system, utilizing a semiconductor camera, permits high quantitative analysis by virtue of its low scatter radiation and high sensitivity. Therefore, this system may contribute to molecular imaging of small animals and basic medical research. Key words: semiconductor detectors, small animal imaging, single photon emission computed tomography