CONNECTIVE-TISSUE ABNORMALITIES IN MRL/1 MICE
CONNECTIVE-TISSUE ABNORMALITIES IN MRL/1 MICE
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DOI：
10.1136/ard.45.6.512
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发表时间：
1986-06-01
影响因子：
27.4
通讯作者：
WILLOUGHBY, DA
中科院分区：
文献类型：
--
作者：
EDWARDS, JCW;COOKE, A;WILLOUGHBY, DA
描述了MRL/1小鼠四肢结缔组织的病理变化。滑膜内层和皮下组织均可见多形或大单个核细胞的局灶浸润，或两者兼而有之。浸润在一些病例中与血管炎有关。关节和脚垫内、周围均可见无定形物质沉积。与典型的“纤维蛋白”相比，该材料颗粒性更强，折射性更强，Feulgen反应呈阳性。它没有被栅栏细胞包围，当在滑膜组织中看到时，通常与滑膜衬里细胞的变化无关。关节内病变与关节外病变无明显差异。皮下组织的损伤只发生在食物垫上。淋巴细胞浸润不明显，未见卵泡形成。在研究的两个菌落中，只有一个菌落显示滑膜组织中衬里细胞数量显著增加。运动后的动物与对照组的疾病分布和严重程度相似。通过对未标记部分的评估，所有描述的病变都与正常对照小鼠和MRL/++小鼠的非特异性炎性病变区分开来。讨论了这些结缔组织病变与人类慢性滑膜炎中发现的变化之间的关系。
Pathological changes in the connective tissue of the limbs of MRL/1 mice are described. Focal infiltrates of polymorphs or large mononuclear cells, or both, were seen both in synovial lining and subcutaneous tissue. Infiltrates were associated with vasculitis in some cases. Deposits of amorphous material were seen in and around joints and in foot pads. The material was more particulate and refractile than typical ''fibrinoid'' and showed a positive Feulgen reaction. It was not surrounded by palisading cells and when seen in synovial tissue was not usually associated with changes in synovial lining cells. No obvious difference was seen between intra-articular and extra-articular lesions. Lesions in subcutaneous tissue occurred exclusively in the food pads. Lymphocyte infiltration was not prominent at any site and no follicle formation was seen. Of two colonies studied, only one showed a significant increase in lining cell numbers in synovial tissue. Exercised animals had a similar distribution and severity of disease to those of matched controls. All lesions described were distinguishable from non-specific inflammatory lesions in normal control mice and MRL/++ mice on assessment of unmarked sections. The relation between these connective tissue lesions and the changes found in human chronic synovitis is discussed.