Mesenchymal stem cell-derived exosomes: Shaping the next era of stroke treatment.
Mesenchymal stem cell-derived exosomes: Shaping the next era of stroke treatment.
复制标题
DOI：
10.1002/nep3.30
复制
发表时间：
2023-12
期刊：
影响因子：
--
通讯作者：
Arshi Waseem;Saudamini;Rizwanul Haque;Miroslaw Janowski;Syed Shadab Raza
中科院分区：
文献类型：
--
作者：
Arshi Waseem;Saudamini;Rizwanul Haque;Miroslaw Janowski;Syed Shadab Raza
基于外泌体的治疗作为解决缺血性中风所面临的各种问题的可行方法正在获得牵引力。这些主要由间充质干细胞（MSC）产生的细胞外囊泡表现出许多具有实质性治疗潜力的特性。外泌体对于中风治疗特别有吸引力，因为它们的低免疫原性、有效的货物运输和穿过血脑屏障的能力。它们的不同作用包括神经保护、血管生成刺激、炎症反应调节和细胞死亡途径衰减，协同促进神经元存活、组织再生和功能恢复。外泌体也显示出作为早期中风识别和定制治疗方案的诊断指标的潜力。尽管有这些有前途的品质，目前基于外泌体的治疗方法有一些局限性。细胞类型之间外泌体释放的异质性、标准化和分离技术的困难以及与剂量和靶向给药相关的并发症需要进行广泛的研究。深入了解外泌体过程及其在细胞环境中复杂的相互作用至关重要。为了提高基于外泌体的药物的实用性和有效性，研究工作必须集中在改进生产工艺、制定可靠的评估标准和开发大规模分离技术上。总之，外泌体的多功能特性为改变中风治疗和显着改善患者预后提供了新途径。
Exosome-based treatments are gaining traction as a viable approach to addressing the various issues faced by an ischemic stroke. These extracellular vesicles, mainly produced by Mesenchymal Stem Cells (MSCs), exhibit many properties with substantial therapeutic potential. Exosomes are particularly appealing for stroke therapy because of their low immunogenicity, effective cargo transport, and ability to cross the blood-brain barrier. Their diverse effects include neuroprotection, angiogenesis stimulation, inflammatory response modulation, and cell death pathway attenuation, synergistically promoting neuronal survival, tissue regeneration, and functional recovery. Exosomes also show potential as diagnostic indicators for early stroke identification and customized treatment options. Despite these promising qualities, current exosome-based therapeutics have some limitations. The heterogeneity of exosome release among cell types, difficulty in standardization and isolation techniques, and complications linked to dosage and targeted administration necessitates extensive investigation. It is critical to thoroughly understand exosomal processes and their complicated interactions within the cellular milieu. To improve the practicality and efficacy of exosome-based medicines, research efforts must focus on improving production processes, developing robust evaluation criteria, and developing large-scale isolation techniques. Altogether, exosomes' multifunctional properties offer a new route for transforming stroke treatment and significantly improving patient outcomes.