An immunoelectron-microscopical observation of mouse juxtaglomerular cells in the case of experimental hydronephrosis.
An immunoelectron-microscopical observation of mouse juxtaglomerular cells in the case of experimental hydronephrosis.
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实验性肾积水情况下小鼠肾小球旁细胞的免疫电镜观察。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
M. Sugimura
中科院分区：
文献类型：
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作者：
Y. Kon;Y. Hashimoto;K. Murakami;M. Sugimura
应用免疫电镜技术观察了实验性肾积水大鼠输尿管结扎后1个月肾小球（含肾素）细胞的变化。观察到两种类型的颗粒，电子致密（D）和透明（L）。D型颗粒较L型颗粒标记更强。颗粒介于D型和L型之间，并观察到D型的胞吐作用。在只含有D型的细胞中，金颗粒仅限于颗粒，而在含有D型和L型颗粒的细胞中，颗粒分散在整个细胞质胞液中。作者对JG细胞释放肾素的机制进行了讨论。
Changes in juxtaglomerular (JG; renin-containing) cells in experimental hydronephrosis 1 month after ureteral ligation were investigated with immunoelectron-microscopical techniques. Two types of granules, electron dense (D) and lucent (L), were observed. D type granules were labeled more intensely with gold particles than those of L type. Granules intermediate between D and L types and exocytosis of D types were observed. In the cells containing D types exclusively, gold particles were restricted to the granules, whereas in the cells containing both D and L type granules, the particles were scattered throughout the cytoplasmic cytosol. The authors discuss the mechanisms of renin release in JG cells.