COMPARISON OF RANITIDINE AND CIMETIDINE IN THE TREATMENT OF GASTRIC HYPERSECRETION
COMPARISON OF RANITIDINE AND CIMETIDINE IN THE TREATMENT OF GASTRIC HYPERSECRETION
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DOI：
10.7326/0003-4819-100-1-52
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发表时间：
1984-01-01
影响因子：
39.2
通讯作者：
JENSEN, RT
中科院分区：
文献类型：
--
作者：
COLLEN, MJ;HOWARD, JM;JENSEN, RT
The H2-histamine receptor antagonists, cimetidine and ranitidine, were compared for their abilities to control acid secretion on a short- and long-term basis in 13 patients with gastric hypersecretory disorders. The rate of onset of action did not differ between the 2 drugs. The actions of both drugs were increased by an anticholinergic agent [either propantheline bromide or isopropamide iodide], and there was a close correlation between the daily maintenance dose of each drug needed to control acid secretion. Ranitidine was 3-fold more potent than cimetidine and no male patient developed breast changes or impotence while taking ranitidine. Treatment with high doses of ranitidine for 6-25 mo. was not associated with hepatic or hematologic toxicity or alterations of serum gastrin levels, but was associated with a significantly lower serum creatinine level than that seen with cimetidine therapy. Evidently, ranitidine can adequately inhibit acid secretion in patients with gastric hypersecretory disorders; is safe at high doses; does not cause the antiandrogen side effects frequently seen with high doses of cimetidine; and is 3-fold more potent than cimetidine. Patients who are relatively resistant to cimetidine will have proportional resistance to ranitidine.
