Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects?: Results of the trans Fatty Acids Collaboration (TRANSFACT) study
Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects?: Results of the trans Fatty Acids Collaboration (TRANSFACT) study
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DOI：
10.1093/ajcn/87.3.558
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发表时间：
2008-03-01
影响因子：
7.1
通讯作者：
Sebedio, Jean-Louis
中科院分区：
文献类型：
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作者：
Chardigny, Jean-Michel;Destaillats, Frederic;Sebedio, Jean-Louis
背景：单不饱和反式脂肪酸（tfa）的摄入增加了心血管疾病（CVD）的风险。工业生产的tfa和天然来源的tfa对心血管疾病风险标志物的影响之间的推定差异此前未在健康受试者中进行过调查。目的：我们旨在比较工业生产的tfa和天然来源的tfa对健康受试者的HDL和LDL胆固醇、脂蛋白颗粒大小和分布、载脂蛋白和其他脂质的影响。设计：在随机、双盲、对照、交叉设计中，46名健康受试者（22名男性和24名女性）食用了来自这两种来源的含有反式脂肪酸的食物（11-12克/天，约占每日能量的5%）。结果：40名受试者（19名男性，21名女性）完成了研究。与工业生产来源的tfa相比，天然来源的tfa显著（P = 0.012）增加了女性的高密度脂蛋白胆固醇，而男性没有。食用天然来源的tfa后，在女性中观察到ldl -胆固醇浓度显著（P = 0.001）增加，而在男性中没有。载脂蛋白（apo）B和apoA1浓度证实了LDL和HDL胆固醇的变化。对脂蛋白亚类的分析表明，天然来源的tfa只改变了高密度脂蛋白和低密度脂蛋白的浓度，而工业来源的tfa则没有改变。结论：本研究表明，工业生产的tfa和天然来源的tfa对女性心血管疾病危险因素的影响不同。tfa降低高密度脂蛋白胆固醇的特性似乎是特定于工业来源的。然而，在目前的研究中，很难得出结论，即来自任何来源的tfa对这些正常血脂受试者的绝对心血管疾病风险的影响。所观察到的性别和异构体特异性效应的机制值得进一步研究。
Background: The consumption of monounsaturated trans fatty acids (TFAs) increases the risk of cardiovascular disease (CVD). Putative differences between the effects of TFAs from industrially produced and natural sources on CVD risk markers were not previously investigated in healthy subjects.Objective: We aimed to compare the effects of TFAs from industrially produced and natural sources on HDL and LDL cholesterol, lipoprotein particle size and distribution, apolipoproteins, and other lipids in healthy subjects.Design: In a randomized, double-blind, controlled, crossover design, 46 healthy subjects (22 men and 24 women) consumed food items containing TFAs (11-12 g/d, representing approximate to 5% of daily energy) from the 2 sources.Results: Forty subjects (19 men and 21 women) completed the study. Compared with TFAs from industrially produced sources, TFAs from natural sources significantly (P = 0.012) increased HDL cholesterol in women but not in men. Significant (P = 0.001) increases in LDL-cholesterol concentrations were observed in women, but not in men, after the consumption of TFAs from natural sources. Apolipoprotein (apo)B and apoA1 concentrations confirmed the changes observed in LDL and HDL cholesterol. Analysis of lipoprotein subclass showed that only large HDL and LDL concentrations were modified by TFAs from natural sources but not by those from industrially produced sources.Conclusions: This study shows that TFAs from industrially produced and from natural sources have different effects on CVD risk factors in women. The HDL cholesterol-lowering property of TFAs seems to be specific to industrial sources. However, it is difficult in the present study to draw a conclusion about the effect of TFAs from either source on absolute CVD risk in these normolipidemic subjects. The mechanism underlying the observed sex- and isomer-specific effects warrants further investigation.