Heavy metal redistribution mechanism assisted magnetic separation for highly-efficient removal of lead and cadmium from human blood
Heavy metal redistribution mechanism assisted magnetic separation for highly-efficient removal of lead and cadmium from human blood
复制标题
重金属再分配机制辅助磁分离高效去除人体血液中的铅和镉
DOI：
10.1016/j.jcis.2018.10.095
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发表时间：
2019
影响因子：
9.9
通讯作者：
Bai Zhiming
中科院分区：
文献类型：
--
作者：
Guo Xueyi;Wang Weijia;Yuan Xiuhong;Yang Ying;Tian Qinghua;Xiang Yang;Sun Yan;Bai Zhiming
基于磁性纳米捕获剂（MNCA）的磁分离技术被认为是一种很有前途的快速分离血液中重金属的方法。有限的去除效率和潜在的生物安全风险是基于MNCA的磁分离的临床应用的主要挑战。在这里，我们报告了一个高效的MNCA为基础的磁分离血液中的重金属在连续多级吸附模式。详细研究了MNCA与血液成分（如血细胞和血浆蛋白）之间的相互作用以及MNCA诱导的细胞免疫应答。定量分析了重金属在血液中的分布和再分布。结果表明，浓度依赖性再分配可以增加重金属与MNCA之间的接触，从而提高重金属的去除效率。以间歇模式和连续模式测试去除性能。结果表明，采用连续多级吸附模式，在120 min内，血液中Pb和Cd的去除率分别为97.97%和96.53%，血液中Pb和Cd的残留浓度分别从400 μg L− 1降至8.11 μg L− 1和13.84 μg L−1。本研究为磁分离治疗重金属中毒提供了一条有效的途径。
Magnetic nano capture agent (MNCA)-based magnetic separation is considered as a promising approach to rapidly isolate heavy metals from blood. Limited removal efficiency and potential biosafety risks are the major challenges for the clinical use of MNCA-based magnetic separation. Here, we report a highly-efficient MNCA-based magnetic separation of heavy metals from blood in continuous multi-stage adsorption mode. The interactions between MNCA and blood components (e.g.blood cells and plasma proteins) and the MNCA-induced cellular immune responses are studied in detail. The distribution and redistribution of heavy metals in blood are quantitatively analyzed. It demonstrates that concentration dependent redistribution can increase the contact between heavy metals and MNCA, leading to improvement on heavy metal removal efficiency. The removal performance is tested in batch mode and in continuous mode. Results show that 97.97% of Pb and 96.53% of Cd are removed from blood in 120 min using continuous multi-stage adsorption mode, and the residual concentrations of Pb and Cd in blood decrease from 400 μg L−1to 8.11 μg L−1and 13.84 μg L−1, respectively. This study paves an effective way for heavy metal intoxication therapy by MNCA-based magnetic separation.