Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making
Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making
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DOI：
10.1016/j.jpsychires.2013.08.003
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发表时间：
2013-11-01
影响因子：
4.8
通讯作者：
Remington, Gary
中科院分区：
文献类型：
--
作者：
Fervaha, Gagan;Graff-Guerrero, Ariel;Remington, Gary
背景：动机障碍是精神分裂症的核心特征，尽管有大量报告使用临床评分量表研究这一特征，但缺乏客观的行为评估。在这里，我们使用转化范式来衡量精神分裂症患者的激励动机。方法：16 名稳定的精神分裂症门诊患者和 16 名匹配的健康对照者完成了奖励任务努力支出的修改版本，该任务考虑了运动能力的差异。简而言之，受试者接受了一系列试验，他们可以选择付出更大的努力来获得更大的金钱奖励，而不是选择付出更少的努力来获得更小的奖励。此外，某次试验获得资金的概率也各不相同，分别为 12%、50% 和 88%。还评估了临床和其他与奖励相关的变量。结果：在高但不确定（即 50% 和 88% 概率）激励值的试验中，患者选择付出明显少于对照组的更大努力，这与动机缺失和神经认知缺陷有关。还注意到其他异常，但与不同的临床变量有关，例如冲动（低奖励和 12% 的概率）。这些动机缺陷并不是由于奖励学习、奖励评估或享乐能力方面的群体差异造成的。结论：我们的研究结果为精神分裂症的奖励动机缺陷提供了新的支持。临床动机缺失与成本效益决策过程中的努力计算受损有关。这种客观的翻译范式可能会指导未来对这些动机障碍背后的神经回路的研究。 (C) 2013 Elsevier Ltd. 保留所有权利。
Background: Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia.Methods: Sixteen stable outpatients with schizophrenia and sixteen matched healthy controls completed a modified version of the Effort Expenditure for Rewards Task that accounts for differences in motoric ability. Briefly, subjects were presented with a series of trials where they may choose to expend a greater amount of effort for a larger monetary reward versus less effort for a smaller reward. Additionally, the probability of receiving money for a given trial was varied at 12%, 50% and 88%. Clinical and other reward-related variables were also evaluated.Results: Patients opted to expend greater effort significantly less than controls for trials of high, but uncertain (i.e. 50% and 88% probability) incentive value, which was related to amotivation and neurocognitive deficits. Other abnormalities were also noted but were related to different clinical variables such as impulsivity (low reward and 12% probability). These motivational deficits were not due to group differences in reward learning, reward valuation or hedonic capacity.Conclusions: Our findings offer novel support for incentive motivation deficits in schizophrenia. Clinical amotivation is associated with impairments in the computation of effort during cost-benefit decision-making. This objective translational paradigm may guide future investigations of the neural circuitry underlying these motivational impairments. (C) 2013 Elsevier Ltd. All rights reserved.