Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis
Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis
复制标题
DOI：
10.4161/cc.5.14.2979
复制
发表时间：
2006-07-15
期刊：
影响因子：
4.3
通讯作者：
Silver, Pamela A.
中科院分区：
文献类型：
--
作者：
Auld, Kathryn L.;Silver, Pamela A.
由泛素-蛋白酶体系统介导的蛋白质降解是许多细胞过程的极其重要的调节手段。越来越多的证据表明蛋白酶体通过多种机制参与基因转录的调节，包括转录因子加工和蛋白酶体-染色质关联。最近，基因组方法被用来阐明芽殖酵母中蛋白酶体的转录效应。 1 结果表明蛋白酶体活性在多种功能基因类别（包括核糖体蛋白基因）的转录中发挥积极作用。此外，发现Spt23靶基因的表达需要蛋白酶体活性，独立于该转录因子的蛋白酶体加工，这表明蛋白酶体的两种转录调节形式之间存在协同作用。在这里，我们讨论这些发现的几个含义，包括通过蛋白酶体对核糖体蛋白基因的转录调节，蛋白质合成和蛋白质降解之间可能的反馈机制。
Protein degradation mediated by the ubiquitin-proteasome system is a vitally important means of regulation for many cellular processes. An increasing body of evidence implicates the proteasome in the regulation of gene transcription through a variety of mechanisms, including transcription factor processing and proteasome-chromatin association. Recently a genomic approach was used to elucidate the transcriptional effects of the proteasome in budding yeast. 1 Results indicate a positive role for proteasome activity in the transcription of several functional gene classes, including the ribosomal protein genes. In addition, proteasome activity was found to be required for the expression of Spt23 target genes, independent of the proteasomal processing of this transcription factor, suggesting cooperativity between two forms of transcriptional regulation by the proteasome. Here we discuss several implications of these findings, including a possible feedback mechanism between protein synthesis and protein degradation via the transcriptional regulation of ribosomal protein genes by the proteasome.