Recent Advances in the C-H-Functionalization of the Distal Positions in Pyridines and Quinolines.
Recent Advances in the C-H-Functionalization of the Distal Positions in Pyridines and Quinolines.
复制标题
DOI：
10.1016/j.tet.2015.08.034
复制
发表时间：
2015-11-18
期刊：
影响因子：
2.1
通讯作者：
Larionov OV
中科院分区：
文献类型：
--
作者：
Stephens DE;Larionov OV
本综述总结了吡啶、喹啉和相关氮杂环化合物远端位置 C-H 功能化的最新进展。虽然 C2 位置的功能化早已为人所知，并且由于靠近 N1 而得到促进，但远端位置的区域选择性反应更难以实现，并且直到最近十年才出现。详细讨论了这些合成上重要的氮杂环化合物的过渡金属催化远端 C-H 官能化的最新进展，重点关注反应的范围、位点选择性和机理方面。
This review summarizes recent developments in the C–H-functionalization of the distal positions of pyridines, quinolines and related azaheterocycles. While the functionalization of the C2 position has been known for a long time and is facilitated by the proximity to N1, regioselective reactions in the distal positions are more difficult to achieve and have only emerged in the last decade. Recent advances in the transition metal-catalyzed distal C–H-functionalization of these synthetically-important azaheterocycles are discussed in detail, with the focus on the scope, site-selectivity and mechanistic aspects of the reactions.