Validity of histopathological grading of articular cartilage from osteoarthritic knee joints
Validity of histopathological grading of articular cartilage from osteoarthritic knee joints
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DOI：
10.1136/ard.58.4.208
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发表时间：
1999-04-01
影响因子：
27.4
通讯作者：
Salter, DM
中科院分区：
文献类型：
--
作者：
Ostergaard, K;Andersen, CB;Salter, DM
目的：验证骨性关节炎(OA)关节软骨组织学-组织化学分级系统(HHGS)的有效性。制作正常标本中央区和周边区的切片。从每个OA样本中产生包含严重、中度和轻度OA变化的区域的部分。结果：根据HHGS评分，重度(8.64)和中度(5.83)骨性关节炎的平均评分低于预期(分别为10-14和6-9)，而轻度(5.29)骨性关节炎和正常软骨的中央和外围(2.19)的平均评分高于预期(分别为2-5和0-1)。HHGS能够区分关节软骨和大体正常的OA关节，以及指定为重度OA的区域和其他区域。然而，HHGS没有充分区分被指定为轻度和中度OA的区域。所有区域的敏感度、特异度和效率值差异很大。结论：HHGS对于正常和重度的OA软骨是有效的，但不允许区分关节软骨的轻度和中度的OA改变。
Objectives-To determine the validity of the histological-histochemical grading system (HHGS) for osteoarthritic (OA) articular cartilage.Methods-Human articular cartilage was obtained from macroscopically normal (n 13) and OA (n = 21) knee joints. Sections of central and peripheral regions of normal samples were produced. Sections of regions containing severe, moderate, and mild OA changes were produced from each OA sample. A total of 89 sections were graded by means of the HHGS (0-14) twice by three observers.Results-Average scores for regions designated severe (8.64) and moderate (5.83) OA were less than the expected (10-14 and 6-9, respectively) according to the HHGS, whereas average scores for the region designated mild (5.29) OA and central and peripheral regions (2.19) of normal cartilage were higher than expected (2-5 and 0-1, respectively). The HHGS was capable of differentiating between articular cartilage from macroscopically normal and OA joints and between the region designated severe OA and other regions. However, the HHGS did not adequately differentiate between regions designated mild and moderate OA. Values for sensitivity, specificity, and efficiency for all regions varied considerably.Conclusion-The HHGS is valid for normal and severe OA cartilage, but does not permit distinction between mild and moderate OA changes in articular cartilage.