Copper deficiency masquerading as myelodysplastic syndrome
Copper deficiency masquerading as myelodysplastic syndrome
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DOI：
10.1182/blood-2002-01-0256
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发表时间：
2002-08-15
期刊：
影响因子：
20.3
通讯作者：
Prchal, JT
中科院分区：
文献类型：
--
作者：
Gregg, XT;Reddy, V;Prchal, JT
我们描述了一位患有严重中性粒细胞减少症并依赖红细胞输注的女性，她之前接受过 Billroth II 手术，其骨髓 (BM) 显示出典型的骨髓增生异常综合征 (MDS) 的形态特征，伴有环状铁粒幼细胞。在用促红细胞生成素和粒细胞集落刺激因子治疗后，她的贫血和严重中性粒细胞减少症暂时逆转。由于在接受生长因子期间复发，患者被转诊进行同种异体骨髓移植。移植前营养评估显示严重缺铜，通过铜治疗，她的血液学异常得到了完全解决。该病例表明，铜缺乏应该成为铁粒幼细胞性MDS鉴别诊断的一个组成部分，即使对于不需要肠外营养的患者也是如此。 (C) 2002 年，美国血液学会。
We describe a woman with severe neutropenia and dependency on red blood cell transfusions who had previously undergone Billroth II surgery and whose bone marrow (BM) showed morphologic characteristics typical of myelodysplastic syndrome (MDS) with ringed sideroblasts. She had transient reversal of anemia and severe neutropenia after therapy with erythropoietin and granulocyte colony-stimulating factor. Because of relapse while receiving growth factors, the patient was referred for allogeneic BM transplantation. A pretransplantation nutritional evaluation revealed severe copper deficiency, and her hematologic abnormalities resolved fully with,copper therapy. This case shows that copper deficiency should be an integral part of the differential diagnosis of sideroblastic MDS, even in patients not requiring parenteral nutrition. (C) 2002 by The American Society of Hematology.