Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography
Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography
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DOI：
10.1002/jmri.21474
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发表时间：
2008-09-01
影响因子：
4.4
通讯作者：
Towner, Rheal A.
中科院分区：
文献类型：
--
作者：
Asanuma, Taketoshi;Doblas, Sabrina;Towner, Rheal A.
目的：目的应用纤维束成像技术评价抗胶质瘤药物苯基N-叔丁基硝酮（PBN）对胶质瘤神经纤维的作用。纤维束成像方法能够区分不同的肿瘤类型。材料与方法：将C6或F98细胞分别注入雄性Fischer 344大鼠脑皮质内。在细胞植入之前或之后开始PBN处理。肿瘤生长监测扩散张量成像（DTI）和纤维束成像使用扩散加权梯度在30个非共线方向。神经纤维束描记术我们能够评估PBN对大鼠脑中侵袭性胶质瘤生长的保护作用。PBN提供了对肿瘤引起的缺血和肿瘤invasion.Results的神经纤维的保护：虽然质子密度加权（PDW）和T2加权（T2 W）图像没有显示C6和F98胶质瘤无水肿之间的任何差异，表观扩散系数（ADC）和分数各向异性（FA）地图能够区分这两个肿瘤模型。纤维束成像用于可视化C6胶质瘤诱导的肿瘤周围组织的缺血，而F98胶质瘤被发现浸润并渗透到胼胝体（CC）中。在胶质瘤生长过程中，发现神经纤维在肿瘤与周围组织之间的边界区域消失。PBN治疗可抑制胶质瘤生长，并伴随周围组织的变化。结论：通过使用PBN无创监测神经纤维完整性和连接性的程度，
Purpose: To apply fiber tractography to assess the effect of a possible antiglioma drug, phenyl N-tert-butyl nitrone (PBN), on glioma-affected neuronal fibers. The fiber tractography method was able to differentiate between different tumor types. such as the C6 and F98 rat glioma models.Materials and Methods: C6 or F98 cells were intracranially injected into the cortex of male Fischer 344 rats. PBN treatment was initiated before or after cell implantation. Tumor growth was monitored with diffusion tensor imaging (DTI) and fiber tractography using diffusion-weighting gradients in 30 noncolinear directions. neuronal fiber tractography. we were able to evaluate the protective effect of PBN against invasive glioma growth in rat brains. PBN provided protection of the neuronal fibers against tumor-induced ischemia and tumor invasion.Results: Although proton density-weighted (PDw) and T2-weighted (T2w) images did not show any difference between C6 and F98 gliomas without edema, the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were able to discriminate between these two tumor models. Fiber tractography was used to) visualize C6 glioma-induced ischemia of tumor-surrounding tissues, whereas F98 glioma was found to infiltrate and penetrate into the corpus callosum (CC). During glioma growth, neuronal fibers were found to disappear at the border regions between the tumor and surrounding tissues. PBN treatment was shown to inhibit glioma growth with accompanying changes in the surrounding tissue.Conclusion: By noninvasively monitoring the degree of neuronal fiber integrity and connectivity with the use of