A central role for long non-coding RNA in cancer.
A central role for long non-coding RNA in cancer.
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DOI：
10.3389/fgene.2012.00017
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发表时间：
2012
影响因子：
3.7
通讯作者：
Triche TJ
中科院分区：
文献类型：
--
作者：
Mitra SA;Mitra AP;Triche TJ
长链非编码RNA（ncRNA）已被证明可以调节支持正常细胞功能的重要生物过程。这些基本功能的异常调节可以促进肿瘤的发展。在这篇综述中，我们强调了这类独特的ncRNA在控制细胞生长、侵袭和转移等机制的癌症相关通路中所起的调节作用的重要性。我们还强调了使用这些独特的RNA作为恶性肿瘤诊断和预后生物标志物的可能性。
Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prognostic biomarkers in malignancies.