Differences in apolipoproteins and low-density lipoprotein subfractions in postmenopausal women on and off estrogen therapy: results from the Framingham Offspring Study.
Differences in apolipoproteins and low-density lipoprotein subfractions in postmenopausal women on and off estrogen therapy: results from the Framingham Offspring Study.
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DOI：
10.1016/0026-0495(90)90162-6
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发表时间：
1990-10
期刊：
影响因子：
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通讯作者：
H. Campos;P. Wilson;D. Jimenez;J. Mcnamara;J. Ordovás;E. Schaefer
中科院分区：
文献类型：
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作者：
H. Campos;P. Wilson;D. Jimenez;J. Mcnamara;J. Ordovás;E. Schaefer
在一些研究中，绝经后妇女使用雌激素与降低冠状动脉疾病（CAD）的风险有关，这可能是由于雌激素对血浆脂蛋白的有利作用。为了检验这种影响，我们研究了来自弗雷明汉后代研究的180名绝经后妇女，根据绝经类型（自然或卵巢切除）和雌激素的使用进行了选择。我们测定了空腹血浆总胆固醇、甘油三酯、极低密度脂蛋白（VLDL）胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和载脂蛋白（apo） A-I和B浓度，以及LDL颗粒大小（LDL 1至LDL 6）。无论绝经类型如何，服用雌激素的绝经后妇女的载脂蛋白A-I水平显著升高（P< 0.005），舒张压和血糖水平显著降低（P< 0.05）。服用口服雌激素的妇女的高密度脂蛋白胆固醇水平也较高，但差异仅在卵巢切除术组有统计学意义（P< 0.02）。服用雌激素的自然绝经妇女的总胆固醇、VLDL胆固醇和LDL胆固醇水平显著低于未服用雌激素的自然绝经妇女（P< 0.01）。在自然绝经组和卵巢切除术组中，雌激素使用者和非雌激素使用者在甘油三酯水平或LDL颗粒评分方面没有发现显著差异。这些数据表明，绝经后妇女使用雌激素与血浆载脂蛋白A-I水平显著升高和低密度脂蛋白胆固醇浓度降低相关。
The use of estrogens by postmenopausal women has been associated with reduced risk of coronary artery disease (CAD) in some studies, possibly due to favorable effects of estrogens on plasma lipoproteins. In order to examine such effects, we studies 180 postmenopausal women from the Framingham Offspring Study, selected by type of menopause (natural or oophorectopic) and estrogen use. We determined fasting plasma total cholesterol, triglyceride, very-low-density lipoprotein (VLDL) cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) A-I and B concentrations, as well as LDL particle size (LDL 1 to LDL 6). Apo A-I levels were significantly (P< .005) higher, and diastolic blood pressure and glucose levels were significantly (P< .05) lower in postmenopausal women taking estrogens regardless of type of menopause. HDL cholesterol levels were also higher in women taking oral estrogens, but differences were significant only for the oophorectomized group (P< .02). Total cholesterol, VLDL cholesterol, and LDL cholesterol levels were significantly lower (P< .01) in women with natural menopause who were taking estrogens than in women with natural menopause not taking this medication. No significant differences between estrogen users and nonusers were found with regard to triglyceride levels or LDL particle score, in either the natural menopause or oophorectomy groups. These data indicate that estrogen use in postmenopausal women is associated with significantly elevated plasma apo A-I levels and decreased LDL cholesterol concentrations.