Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.
Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.
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DOI：
10.1093/nar/gkr952
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Ciccarelli FD
中科院分区：
文献类型：
--
作者：
D'Antonio M;Pendino V;Sinha S;Ciccarelli FD
不断增加的基因突变与肿瘤的发生和发展有因果关系（癌基因），需要开发工具来存储和分析它们。癌症基因网络（NCG 3.0）收集了在16种不同癌症类型中发现的1494种癌症基因的突变信息。这些基因来自癌症基因普查，以及18个全外显子组和11个全基因组筛查的癌症样本。对于每个癌症基因，NCG 3.0提供了基因特征的总结和与其他数据库的交叉参考。此外，它还描述了癌症基因和所有相关基因的可重复性、进化起源、同源性、网络特性、相互作用伙伴、microRNA调控和功能角色。这种整合的信息网络可以用来更好地描述癌症基因在其作用的系统背景下的特征。这些数据还可以用来识别与已知癌症基因具有相同特性的新候选基因，因此可能在癌症中发挥类似的作用。NCG 3.0可在http://bio.ifom-ieo-campus.it/ncg免费获得。
The identification of a constantly increasing number of genes whose mutations are causally implicated in tumor initiation and progression (cancer genes) requires the development of tools to store and analyze them. The Network of Cancer Genes (NCG 3.0) collects information on 1494 cancer genes that have been found mutated in 16 different cancer types. These genes were collected from the Cancer Gene Census as well as from 18 whole exome and 11 whole-genome screenings of cancer samples. For each cancer gene, NCG 3.0 provides a summary of the gene features and the cross-reference to other databases. In addition, it describes duplicability, evolutionary origin, orthology, network properties, interaction partners, microRNA regulation and functional roles of cancer genes and of all genes that are related to them. This integrated network of information can be used to better characterize cancer genes in the context of the system in which they act. The data can also be used to identify novel candidates that share the same properties of known cancer genes and may therefore play a similar role in cancer. NCG 3.0 is freely available at http://bio.ifom-ieo-campus.it/ncg.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
2
作者：
Anelli, Viviana;Santoriello, Cristina;Mione, Marina
通讯作者：
Mione, Marina
DOI：
10.1056/nejmoa1005143
发表时间：
2010-12-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ley TJ;Ding L;Walter MJ;McLellan MD;Lamprecht T;Larson DE;Kandoth C;Payton JE;Baty J;Welch J;Harris CC;Lichti CF;Townsend RR;Fulton RS;Dooling DJ;Koboldt DC;Schmidt H;Zhang Q;Osborne JR;Lin L;O'Laughlin M;McMichael JF;Delehaunty KD;McGrath SD;Fulton LA;Magrini VJ;Vickery TL;Hundal J;Cook LL;Conyers JJ;Swift GW;Reed JP;Alldredge PA;Wylie T;Walker J;Kalicki J;Watson MA;Heath S;Shannon WD;Varghese N;Nagarajan R;Westervelt P;Tomasson MH;Link DC;Graubert TA;DiPersio JF;Mardis ER;Wilson RK
通讯作者：
Wilson RK
胰腺神经内分泌肿瘤中经常改变DAXX/ATRX，MEN1和MTOR途径基因。
DOI：
10.1126/science.1200609
发表时间：
2011-03-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiao Y;Shi C;Edil BH;de Wilde RF;Klimstra DS;Maitra A;Schulick RD;Tang LH;Wolfgang CL;Choti MA;Velculescu VE;Diaz LA Jr;Vogelstein B;Kinzler KW;Hruban RH;Papadopoulos N
通讯作者：
Papadopoulos N