Changing patterns of fibronectin, laminin, type IV collagen, and a basement membrane proteoglycan during rat Mullerian duct regression.
Changing patterns of fibronectin, laminin, type IV collagen, and a basement membrane proteoglycan during rat Mullerian duct regression.
复制标题
大鼠苗勒管退化过程中纤连蛋白、层粘连蛋白、IV 型胶原和基底膜蛋白聚糖的变化模式。
DOI：
10.1016/0012-1606(84)90190-8
复制
发表时间：
1984
影响因子：
2.7
通讯作者：
Donahoe,PK
中科院分区：
文献类型：
--
作者：
Ikawa,H;Trelstad,RL;Hutson,JM;Manganaro,TF;Donahoe,PK
IV型胶原蛋白，层粘连蛋白，硫酸乙酰肝素蛋白聚糖和纤维连接蛋白的抗体被用来研究大鼠苗勒管的回归。所有这四种基质成分都位于导管基底膜内的苗勒管周边。随着苗勒管的退化，所有这些基底膜成分的染色变得不规则和不连续。纤维连接蛋白也存在于小肠中，在间充质中变得不可检测，间充质在退化的苗勒管周围凝结。这些数据表明，男性苗勒管周围的细胞外基质的降解是这个结构的回归的中心事件。
Antibodies to type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin were used to study the regression of the rat Mullerian duct. All four of these matrix constituents are located at the perimeter of the Mullerian duct within the ductal basement membrane. As the Mullerian duct regresses, the staining of all of these basement membrane constituents becomes irregular and discontinuous. Fibronectin, which is also present in the interstitium, becomes undetectable in the mesenchyme which condenses around the regressing Mullerian duct. These data indicate that degradation of the extracellular matrix around the male Mullerian duct is a central event in the regression of this structure.