Bacterial Quorum Sensing and Microbial Community Interactions.
Bacterial Quorum Sensing and Microbial Community Interactions.
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DOI：
10.1128/mbio.02331-17
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发表时间：
2018-05-22
期刊：
影响因子：
6.4
通讯作者：
Chandler JR
中科院分区：
文献类型：
--
作者：
Abisado RG;Benomar S;Klaus JR;Dandekar AA;Chandler JR
许多细菌使用一种称为群体感应的细胞间通讯系统来协调种群密度依赖的行为变化。群体感应涉及对可扩散或分泌的信号的产生和响应，其在不同类型的细菌中可以显著变化。在许多物种中，群体感应调节毒力功能，并对发病机制很重要。在过去的半个世纪里，已经有大量的知识积累的分子机制，信号结构，基因调控，和行为反应与群体感应系统在不同的细菌。最近的研究集中在理解细菌社会性背景下的群体感应。对群体感应在合作和竞争微生物相互作用中的作用的研究揭示了群体感应如何协调物种内和物种之间的相互作用。群体感应作为一种社会行为的研究依赖于使用非克隆细菌种群的“合成生态”模型的发展。在这篇综述中，我们讨论了这些模型和最近的进展，了解微生物如何相互作用，利用群体感应。从这些调查中获得的知识有可能指导自然环境中微生物社会性的研究以及治疗细菌感染的新药和疗法的设计。
Many bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, which can vary substantially across different types of bacteria. In many species, quorum sensing modulates virulence functions and is important for pathogenesis. Over the past half-century, there has been a significant accumulation of knowledge of the molecular mechanisms, signal structures, gene regulons, and behavioral responses associated with quorum-sensing systems in diverse bacteria. More recent studies have focused on understanding quorum sensing in the context of bacterial sociality. Studies of the role of quorum sensing in cooperative and competitive microbial interactions have revealed how quorum sensing coordinates interactions both within a species and between species. Such studies of quorum sensing as a social behavior have relied on the development of “synthetic ecological” models that use nonclonal bacterial populations. In this review, we discuss some of these models and recent advances in understanding how microbes might interact with one another using quorum sensing. The knowledge gained from these lines of investigation has the potential to guide studies of microbial sociality in natural settings and the design of new medicines and therapies to treat bacterial infections.