Embryonic Genoarchitecture of the Pretectum in Xenopus laevis: A Conserved Pattern in Tetrapods
Embryonic Genoarchitecture of the Pretectum in Xenopus laevis: A Conserved Pattern in Tetrapods
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DOI：
10.1002/cne.22548
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发表时间：
2011-04-15
影响因子：
2.5
通讯作者：
Gonzalez, Agustin
中科院分区：
文献类型：
--
作者：
Morona, Ruth;Ferran, Jose L.;Gonzalez, Agustin
网络基因活动控制着进化上保守的脊椎动物中枢神经系统的组织遗传组织。基因结构学研究通过识别不同的祖结构域和相应的衍生物来分析每个形态发生场，这些衍生物的基因表达模式显示出独特的组合密码。先前对前前额区（尾间脑）的研究已经确定了鸟类和哺乳动物中保守的三个前后基因结构域。在此，我们研究了两栖动物爪蟾（Xenopus laevis）的胚胎前直肠基因结构，以确定是否有可能定义两栖动物前直肠区域的前后三分区。14个基因的表达模式从早期胚胎阶段定位到变质顶极期，使我们能够确定前顶盖、合拢前、合拢旁和合拢前后结构域的边界，以及一些背腹细分。综上所述，我们的数据为羊膜动物和两栖动物羊膜动物（四足动物）共有的保护结构域和子结构域的保守模式提供了证据，这可以理解为脊椎动物中一般Bauplan的一部分。[j] .中国生物医学工程学报，2016,31(2):444 - 444。(C) 2010 Wiley-Liss, Inc。
Networked gene activities control the evolutionarily conserved histogenetic organization of the central nervous system of vertebrates. Genoarchitectonic studies contribute to the analysis of each morphogenetic field by identifying distinct progenitor domains and corresponding derivatives whose pattern of gene expression shows a unique combinatory code. Previous studies in the pretectal region (caudal diencephalon) have defined three anteroposterior genoarchitectonic domains that are conserved in birds and mammals. Here, we have studied the embryonic pretectal genoarchitecture in the amphibian Xenopus laevis, in order to determine whether it is possible to define a comparable anteroposterior tripartition of the amphibian pretectal area. The expression patterns of 14 genes mapped from early embryonic stages to metamorphic climax allowed us to define the boundaries of the pretectum, the expected precommissural, juxtacommissural, and commissural anteroposterior domains, and some dorsoventral subdivisions. Taken together, our data provide evidence for a conserved pattern of pretectal domains and subdomains, shared by amniotes and amphibian anamniotes (tetrapods), understandable as part of a general Bauplan in vertebrates. J. Comp. Neurol. 519: 1024-1050, 2011. (C) 2010 Wiley-Liss, Inc.