Regulation of fasted blood glucose by resistin
Regulation of fasted blood glucose by resistin
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DOI：
10.1126/science.1092341
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发表时间：
2004-02-20
期刊：
影响因子：
56.9
通讯作者：
Lazar, MA
中科院分区：
文献类型：
--
作者：
Banerjee, RR;Rangwala, SM;Lazar, MA
肥胖和糖尿病之间的联系支持了脂肪细胞在维持血糖稳态方面的内分泌作用。在这里，我们报告缺乏脂肪细胞激素抵抗素的小鼠在禁食后表现出低血糖水平，这是由于肝脏葡萄糖产生减少所致。这在一定程度上是通过激活一磷酸腺苷激活的蛋白激酶和减少肝脏中糖异生酶的表达来实现的。因此，这些数据支持抵抗素在禁食期间维持血糖的生理功能。值得注意的是，抵抗素的缺乏减少了正常情况下与体重增加相关的空腹后血糖的增加，这表明抵抗素在调节与肥胖相关的高血糖中发挥了作用。
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.