The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.
The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.
复制标题
作者：
神经影像（例如功能磁共振成像）信号被视为局部神经活动的统一代表。通过在警觉的、忙于任务的猕猴视觉皮层中同时记录电极和神经影像（固有光学成像）信号，我们最近观察到了一个与局部尖峰或场电位关系不大的大量预期试验相关的神经影像信号。我们使用这些相同的技术来研究这种与试验相关的信号与在整个刺激强度范围内（包括完全黑暗）的刺激诱发反应的相互作用。我们发现这两个信号可以分离，并在整个范围内线性相加。刺激诱发成分与局部尖峰呈线性相关，因此可用于获得局部神经活动的精确可靠的估计。然而，与试验相关的信号可能具有独特的神经机制，并且在根据神经影像信号估计局部神经尖峰时，未能正确解释它可能会导致重大错误。
Neuroimaging (for example, functional magnetic resonance imaging) signals are taken as a uniform proxy for local neural activity. By simultaneously recording electrode and neuroimaging (intrinsic optical imaging) signals in alert, task-engaged macaque visual cortex, we recently observed a large anticipatory trial-related neuroimaging signal that was poorly related to local spiking or field potentials. We used these same techniques to study the interactions of this trial-related signal with stimulus-evoked responses over the full range of stimulus intensities, including total darkness. We found that the two signals could be separated, and added linearly over this full range. The stimulus-evoked component was related linearly to local spiking and, consequently, could be used to obtain precise and reliable estimates of local neural activity. The trial-related signal likely has a distinct neural mechanism, however, and failure to account for it properly could lead to substantial errors when estimating local neural spiking from the neuroimaging signal.
登录
查看更多内容
影响因子：
5.7
作者：
Cohen, MS
通讯作者：
Cohen, MS
影响因子：
1.8
作者：
Grill-Spector, K;Malach, R
通讯作者：
Malach, R
影响因子：
16.2
作者：
Gardner, JL;Sun, P;Cheng, K
通讯作者：
Cheng, K
影响因子：
1.8
作者：
Boynton, GM;Demb, JB;Heeger, DJ
通讯作者：
Heeger, DJ
影响因子：
5.3
作者：
Donner, Tobias H.;Sagi, Dov;Heeger, David J.
通讯作者：
Heeger, David J.