Embryonic assembly of a central pattern generator without sensory input
Embryonic assembly of a central pattern generator without sensory input
复制标题
DOI：
10.1038/416174a
复制
发表时间：
2002-03-14
期刊：
影响因子：
64.8
通讯作者：
Bate, M
中科院分区：
文献类型：
--
作者：
Suster, ML;Bate, M
运动依赖于感觉信息与中枢回路活动的整合，中枢回路在运动神经中产生模式化放电，并将其传递到相应的肌肉（1，2）。孤立的中枢网络产生虚构的运动节律（在没有运动的情况下记录），表明运动输出的基本模式取决于这些中枢回路的内在连接性和电特性（3，4）。需要感觉输入来响应于真实的运动的实际情况来修改运动活动的模式。我们理解运动回路是如何指定和组装的一个中心问题是，在这种系统发展的过程中，需要多大程度的感觉输入（5）。在这里，我们描述了消除感觉功能和结构的果蝇胚胎和幼虫的蠕动运动模式的发展的影响。我们推断，蠕动爬行电路的发展完全没有感觉输入，然而，这个电路的整合到实际的运动模式需要额外的信息，从感觉系统。在没有感觉输入的情况下，运动的极性是混乱的，向后的蠕动波以向前的蠕动为代价占主导地位。
Locomotion depends on the integration of sensory information with the activity of central circuitry, which generates patterned discharges in motor nerves to appropriate muscles(1,2). Isolated central networks generate fictive locomotor rhythms (recorded in the absence of movement), indicating that the fundamental pattern of motor output depends on the intrinsic connectivity and electrical properties of these central circuits(3,4). Sensory inputs are required to modify the pattern of motor activity in response to the actual circumstances of real movement. A central issue for our understanding of how locomotor circuits are specified and assembled is the extent to which sensory inputs are required as such systems develop(5). Here we describe the effects of eliminating sensory function and structure on the development of the peristaltic motor pattern of Drosophila embryos and larvae. We infer that the circuitry for peristaltic crawling develops in the complete absence of sensory input; however, the integration of this circuitry into actual patterns of locomotion requires additional information from the sensory system. In the absence of sensory inputs, the polarity of movement is deranged, and backward peristaltic waves predominate at the expense of forward peristalsis.