Site specificity of adrenalectomy-induced brain growth.
Site specificity of adrenalectomy-induced brain growth.
复制标题
肾上腺切除术诱导的大脑生长的位点特异性。
DOI：
10.1016/0014-4886(88)90229-4
复制
发表时间：
1988
影响因子：
5.3
通讯作者：
Devenport,LD
中科院分区：
文献类型：
--
作者：
Thomas,TL;Devenport,LD
婴儿、青少年和成年人的大脑发育受皮质酮调节。这项研究旨在确定这种调制是否仅限于某些特定的大脑区域，以及所揭示的生长模式是否在不同品系的大鼠中一致。将年轻雌性Sprague-Dawley衍生大鼠肾上腺切除（ADX）或假手术（Sham），并在处死进行组织学分析前45天使其成熟。采用多平面脑组织切片，投影显微镜显示。在检查的21个部位中，ADX对新皮质组织和有髓纤维束的影响最大。唯一受影响的其他大脑区域是丘脑，由于ADX，丘脑显示出显着的增宽。与此相反，archicortical结构显着不受ADX。无论是海马，从各种平面测量，也不是在隔区的核受到ADX的增长增加。这种ADX位点特异性的一般描述在不同品系的大鼠中保持不变。然而，存在地方差异。在新皮质内，一种菌株的额叶区域增厚最严重，而另一种菌株的枕叶区域受到的影响最强烈。顶叶皮层在两种菌株中的反应相同。敏感与不敏感位点的模式与环境富集所带来的生长增加模式以及2型皮质酮受体的前脑分布相似。
Infant, juvenile, and adult brain growth is modulated by corticosterone. This study was designed to determine whether such modulation is confined to certain specific brain areas, and if the pattern of growth revealed is consistent across strains of rats. Young female Sprague-Dawley-derived rats were either adrenalectomized (ADX) or sham-operated (Sham) and allowed to mature 45 days before they were sacrificed for histological analysis. Fore brain sections were taken at several planes for display by projection microscope. Of the 21 sites examined, ADX exerted its greatest effect upon neocortical tissue and myelinated fiber tracts. The only other brain region affected was thalamus, which exhibited a significant widening as a result of ADX. In contrast, archicortical structures were notably unaffected by ADX. Neither the hippocampus, measured from a variety of planes, nor nuclei in the septal area were subject to increased growth by ADX. This general portrayal of ADX's site specificity held across strains of rats. However, there were local differences. Within the neopallium, the frontal region underwent the greatest thickening in one strain, while the occipital area was most strongly affected in the other. Parietal cortex was equally responsive in both strains. The pattern of sensitive vs insensitive sites bore a resemblance to the pattern of increased growth brought about by environmental enrichment as well as the fore brain distribution of Type 2 corticosterone receptors.