Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study
Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study
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DOI：
10.3945/ajcn.112.045575
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发表时间：
2013-05-01
影响因子：
7.1
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Ozawa, Mio;Ninomiya, Toshiharu;Kiyohara, Yutaka
背景资料：据我们所知，有没有以前的报告，评估饮食模式和痴呆症的风险之间的关联在亚洲population.Objective：我们调查了饮食模式和他们的潜在关联与痴呆症的风险事件在一般Japanese population.Design：一个共同的1006个社区居住的日本科目没有痴呆症，年龄60-79岁，随访中位数为15年。采用降秩回归分析方法，有效地确定了它们的膳食结构。估计风险赋予一个特定的饮食模式对痴呆症的发展计算通过使用考克斯比例风险model.Results：七种饮食模式提取，其中，饮食模式1与高摄入量的大豆和大豆制品，蔬菜，藻类，牛奶和乳制品和低摄入量的大米。在随访期间，271名受试者患上了全因痴呆症。在这些个体中，144名受试者患有阿尔茨海默病（AD），88名受试者患有血管性痴呆（VaD）。校正潜在混杂因素后，全因痴呆、AD和VaD的发生风险降低了0.66（95% CI：0.46，0.95），0.65（95% CI：0.40，1.06）和0.45（95%CI：0.22，0.91），与最低四分位数的受试者相比，饮食模式1得分最高的四分位数的受试者的差异显著。我们的研究结果表明，在日本普通人群中，更高程度地坚持以大豆和大豆制品、蔬菜、藻类、牛奶和乳制品的高摄入量和大米的低摄入量为特征的饮食模式与痴呆症的风险降低有关。美国临床营养杂志2013;97：1076-82。
Background: To our knowledge, there are no previous reports that assessed the association between dietary patterns and risk of dementia in Asian populations.Objective: We investigated dietary patterns and their potential association with risk of incident dementia in a general Japanese population.Design: A total of 1006 community-dwelling Japanese subjects without dementia, aged 60-79 y, were followed up for a median of 15 y. The reduced rank regression procedure was used to efficiently determine their dietary patterns. Estimated risk conferred by a particular dietary pattern on the development of dementia was computed by using a Cox proportional hazards model.Results: Seven dietary patterns were extracted; of these, dietary pattern 1 was correlated with high intakes of soybeans and soybean products, vegetables, algae, and milk and dairy products and a low intake of rice. During the follow-up, 271 subjects developed all-cause dementia. Of these individuals, 144 subjects had Alzheimer disease (AD), and 88 subjects had vascular dementia (VaD). After adjustment for potential confounders, risks of development of all-cause dementia, AD, and VaD were reduced by 0.66 (95% Cl: 0.46, 0.95), 0.65 (95% Cl: 0.40, 1.06), and 0.45 (95% CI: 0.22, 0.91), respectively, in subjects in the highest quartile of score for dietary pattern 1 compared with subjects in the lowest quartile.Conclusion: Our findings suggest that a higher adherence to a dietary pattern characterized by a high intake of soybeans and soybean products, vegetables, algae, and milk and dairy products and a low intake of rice is associated with reduced risk of dementia in the general Japanese population. Am J Clin Nutr 2013;97:1076-82.