Neutrophils and type 1 autoimmune diabetes
Neutrophils and type 1 autoimmune diabetes
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DOI：
10.1097/moh.0000000000000008
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Battaglia, Manuela
中科院分区：
文献类型：
--
作者：
Battaglia, Manuela
综述目的1型糖尿病（T1 D）通常被描述为一种自身免疫性疾病，其中错误的T淋巴细胞活性导致产生胰岛素的胰腺细胞的选择性破坏。新的发现表明，免疫学的图景可能比以前想象的更复杂。本文将重点介绍最近的研究提供了新的见解的假设，中性粒细胞可能参与T1 D的启动和perpetuation.Recent findingsReduced循环中性粒细胞计数与T1 D在人类从糖尿病前期的发病阶段。此外，最近在患有自发性自身免疫性T1 D的小鼠中证实了中性粒细胞在T1 D发病机制中迄今未被承认的作用。总结尽管这些发现尚未经过科学界的仔细审查，但它们表明中性粒细胞-除了巨噬细胞，树突状细胞和淋巴细胞-可能在T1 D免疫病理学中发挥作用。需要进一步的研究，这可能会导致定义新的治疗策略的疾病，迄今已被证明是可控的，但无法治愈。
Purpose of reviewType 1 diabetes (T1D) is commonly portrayed as an autoimmune disease, in which misguided T lymphocyte activities cause selective destruction of insulin-producing pancreatic -cells. New findings suggest that the immunological picture might be more complex than previously imagined. This review will focus on the recent studies that provide new insight into the hypothesis that neutrophils might participate in T1D initiation and perpetuation.Recent findingsReduced circulating neutrophil counts associate with T1D in humans from the pre-diabetic to the onset phases. Additionally, a hitherto unacknowledged role for neutrophils in T1D pathogenesis has recently been demonstrated in mice with spontaneous autoimmune T1D.SummaryAlthough these findings have yet to undergo the scrutiny of the scientific community, they suggest that neutrophils - in addition to macrophages, dendritic cells, and lymphocytes - may play a role in T1D immunopathology. Further research is needed, which might lead to the definition of new therapeutic strategies for a disease that to date has proved controllable but incurable.