Serum FSH bioactivity and inhibin levels in patients with gonadotropin secreting and nonfunctioning pituitary adenomas
Serum FSH bioactivity and inhibin levels in patients with gonadotropin secreting and nonfunctioning pituitary adenomas
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DOI：
10.1007/bf03350773
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发表时间：
1998-06-01
影响因子：
5.4
通讯作者：
Beck-Peccoz, P
中科院分区：
文献类型：
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作者：
Borgato, S;Persani, L;Beck-Peccoz, P
据报道，血清FSH生物活性和抑制素水平可作为真促性腺激素分泌性垂体腺瘤(Gn-OMA)的标志物。为了验证这一假设，我们研究了一系列Gn-OMA或无功能垂体腺瘤(NFPA)患者的FSH生物活性和血清抑制素α-α和α-βA水平。Gn-OMA患者9例(男6例，女3例)，NFPA患者21例(男9例，女12例)，正常对照组30例。用支持细胞芳香酶生物法(SAB)测定FSH生物活性(FSH-B)，用两种非竞争性免疫测定法(IEMA)测定α-α和α-βA抑制素水平。男性Gn-OMA患者血清FSH-I和FSH-B水平分别为5.1~35.5U/L和8.3~48U/L，FSH B/L比值升高2例(2.5和4.1；正常男性0.3~1.5)；女性Gn-OMA患者血清FSH-I和FSH-B水平分别为43.2~162U/L和41.2~112.8 U/L，FSH B/L比值正常。男性患者血清FSH-I和FSH-B水平分别为2.7~10.7U/L和2.4~11.4U/L，女性患者分别为3.4~67.9和4.6~60.8U/L。1例男性FSHB/L比值升高(3.3%)，其余患者FSHB/L比值正常。在Gn-OMA和NFPA患者中，血清a-a抑制素水平正常或低，而在6名绝经后妇女中，有1名a-PA抑制素水平轻微升高(0.9；正常范围
It has been reported that serum FSH bioactivity and inhibin levels can be used as markers of the presence of true gonadotropin-secreting pituitary adenoma (Gn-oma). To verify this hypothesis, we have investigated the bioactivity of FSH and serum inhibin alpha-alpha and alpha-beta A levels in a series of patients with either Gn-oma or nonfunctioning pituitary adenoma (NFPA). Nine patients with Gn-oma (6 men and 3 women), 21 with NFPA (9 men and 12 women) and 30 normal subjects were included in the study. We studied FSH biological activity (FSH-B) by using Sertoli cell aromatase bioassay (SAB) and alpha-alpha and alpha-beta A inhibin levels by two noncompetitive immunometric assays (IEMA). In male patients with Gn-oma, serum immunoreactive FSH (FSH-I) and FSH-B levels ranged from 5.1 to 35.5 U/L and from 8.3 to 48 U/L, respectively, FSH B/l ratio being elevated in 2 (2.5 and 4.1; normal male range: 0.3-1.5), while female patients with Gn-oma had serum FSH-I and FSH-B levels ranging from 43.2 to 162 U/L and from 41.2 to 112.8 U/l, respectively, with a normal FSH B/l ratio. In male patients with NFPA, FSH-I and FSH-B levels ranged from 2.7 to 10.7 U/l and from 2.4 to 11.4 U/l while in females they ranged from 3.4 to 67.9 and from 4.6 to 60.8 U/l, respectively. FSH B/l ratio was elevated in 1 male (3.3) and normal in the remaining patients with NFPA. Serum a-a inhibin levels were normal or low in patients with Gn-oma and NFPA, while a-PA inhibin concentrations were slightly elevated in 1 of 6 postmenopausal women (0.9; normal range