Two Roads Diverge: Weight Loss Interventions and Circulating Amino Acids
Two Roads Diverge: Weight Loss Interventions and Circulating Amino Acids
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DOI：
10.1126/scitranslmed.3002377
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发表时间：
2011-04-27
影响因子：
17.1
通讯作者：
Wang, Thomas J.
中科院分区：
文献类型：
--
作者：
Gerszten, Robert E.;Wang, Thomas J.
在这期《科学转化医学》杂志上，Laferrere及其同事描述了一种代谢产物分析方法，用于研究胃旁路手术（GBP）或饮食干预引起的同等体重减轻后循环代谢组的变化。结果表明，GBP通过与体重减轻不同的机制增强支链氨基酸代谢。这些观察结果提出了这样的可能性，即循环氨基酸的变化在GBP后不久观察到的血糖控制校正中起作用。
In this issue of Science Translational Medicine, Laferrere and colleagues describe a metabolite pro ling approach to investigate changes in the circulating metabolome after equivalent weight loss spurred by either gastric bypass surgery (GBP) or dietary intervention. The results reveal that GBP enhances branched chain amino acid metabolism by mechanisms separate from weight loss. These observations raise the possibility that changes in circulating amino acids play a role in the correction of glycemic control observed shortly after GBP.