Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys.
Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys.
复制标题
恒河猴获得性免疫缺陷综合症（SAIDS）的临床特征。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
M. Gardner
中科院分区：
文献类型：
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作者：
Henrickson Rv;Maul Dh;Lerche Nw;K. Osborn;L. Lowenstine;S. Prahalada;Sever Jl;Madden Dl;M. Gardner
在加州灵长类动物研究中心死亡的一群恒河猴（Macaca mulatta）中发现了一种获得性免疫缺陷综合征。对这些动物的临床评价显示，50%或更多的动物有淋巴结病、体重减轻和腹泻。至少30%有脾肿大、发热、皮肤肿胀和/或关节炎/肌炎。两只动物有纤维肉瘤。19只动物出现贫血，14只出现淋巴细胞减少，4只出现粒细胞减少，3只出现血小板减少。13例组织病理学诊断为肝炎。电泳显示低蛋白血症、低白蛋白血症和低丙种球蛋白血症。许多细菌，原虫，和病毒的代理商被确定，包括巨细胞病毒和白细胞相关疱疹病毒。病理损害包括在生发中心和淋巴结副皮质区的淋巴细胞的严重反应后耗竭。临床和病理变化表明获得性免疫缺陷综合征与人类艾滋病有一些相似之处。猴子的这种疾病可能为研究这种疾病提供一个模型。
A syndrome of acquired immunodeficiency has been identified in a group of rhesus monkeys (Macaca mulatta) which died at the California Primate Research Center. Clinical evaluation of these animals revealed that 50% or more had lymphadenopathy, weight loss, and diarrhea. At least 30% had splenomegaly, fever, cutaneous abscesses and/or arthritis/myositis. Two animals had fibrosarcomas. Anemia was seen in 19 animals, lymphopenia in 14, granulocytopenia in four and thrombocytopenia in three. Hepatitis was diagnosed histopathologically in 13. Electrophoresis revealed hypoproteinemia, hypoalbuminemia and hypogammaglobulinemia. Numerous bacterial, protozoal, and viral agents were identified including cytomegalovirus and leukocyte-associated herpesvirus. Pathologic lesions included severe post-reactive depletion of lymphocytes in germinal centers and paracortical regions of lymph nodes. Clinical and pathologic changes indicate an acquired immunodeficiency syndrome which has some similarities to AIDS in humans. This disease in monkeys may provide a model for studying that disease.