Dynamical resetting of the human brain at epileptic seizures: Application of nonlinear dynamics and global optimization techniques
Dynamical resetting of the human brain at epileptic seizures: Application of nonlinear dynamics and global optimization techniques
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DOI：
10.1109/tbme.2003.821013
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发表时间：
2004-03-01
影响因子：
4.6
通讯作者：
Prasad, A
中科院分区：
文献类型：
--
作者：
Iasemidis, LD;Shiau, DS;Prasad, A
癫痫发作间歇性地发生，是大脑许多区域之间复杂的动态相互作用的结果。通过应用非线性动力学理论和全局最优化理论中的信号处理技术对4例癫痫患者的长期(3.6-12天)连续多道脑电记录进行分析，我们提出了癫痫发作似乎是大脑的动态重置机制的证据，即癫痫发作前动态夹带的脑区在癫痫发作时比其他任何时期更快和更频繁地释放(p<；0.05)。我们期望这些结果能为癫痫的发生、癫痫的干预和控制机制以及其他复杂的生物和物理系统中间歇性时空状态转换的研究提供帮助。
Epileptic seizures occur intermittently as a result of complex dynamical interactions among many regions of the brain. By applying signal processing techniques from the theory of nonlinear dynamics and global optimization to the analysis of long-term (3.6 to 12 days) continuous multichannel electroencephalographic recordings from four epileptic patients, we present evidence that epileptic seizures appear to serve as dynamical resetting mechanisms of the brain, that is the dynamically entrained brain areas before seizures disentrain faster and more frequently (p < 0.05) at epileptic seizures than any other periods. We expect these results to shed light into the mechanisms of epileptogenesis, seizure intervention and control, as well as into investigations of intermittent spatiotemporal state transitions in other complex biological and physical systems.