Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells.
Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells.
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DOI：
10.2147/ott.s34670
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发表时间：
2013-09-13
影响因子：
4
通讯作者：
Nagathihalli NS
中科院分区：
文献类型：
--
作者：
Castellanos JA;Merchant NB;Nagathihalli NS
胰腺导管腺癌是最具侵袭性的实体恶性肿瘤之一，其特点是对当前治疗的反应差，生存率低。最近关于癌症干细胞（CSC）和上皮-间质转化（EMT）在肿瘤发生中的作用的见解使人们对该领域有了进一步的了解，并突出了新的治疗靶点。CSC是癌细胞的一个独特子集，具有分化为其他细胞类型和自我更新的能力，以促进肿瘤扩增的维持。癌细胞从EMT的转变导致增加的迁移和侵袭特性，从而促进转移的开始。EMT是由一个复杂的网络的因素，包括细胞因子，生长因子，异常信号通路，转录因子和肿瘤微环境的调节。有新的证据表明，EMT过程可能会产生CSC，或至少具有干细胞样特性的细胞。我们回顾了这两个过程中涉及的关键途径，用于识别CSC的生物标志物，以及针对胰腺导管腺癌中CSC和EMT的新治疗方法。
Pancreatic ductal adenocarcinoma is one of the most aggressive solid malignancies and is characterized by poor response to current therapy and a dismal survival rate. Recent insights regarding the role of cancer stem cells (CSCs) and epithelial–mesenchymal transition (EMT) in tumorigenesis have brought further understanding to the field and have highlighted new therapeutic targets. CSCs are a distinct subset of cancer cells, with the ability to differentiate into other cell types and self-renew in order to fuel the maintenance of tumor amplification. Transition of a cancer cell from an EMT leads to increased migratory and invasive properties, and thus facilitates initiation of metastasis. EMT is regulated by a complex network of factors that includes cytokines, growth factors, aberrant signaling pathways, transcription factors, and the tumor microenvironment. There is emerging evidence that the EMT process may give rise to CSCs, or at least cells with stem cell-like properties. We review the key pathways involved in both of these processes, the biomarkers used to identify CSCs, and new therapeutic approaches targeting CSCs and EMT in pancreatic ductal adenocarcinoma.