Melatonin: a novel indolamine in oral health and disease.
Melatonin: a novel indolamine in oral health and disease.
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DOI：
10.1155/2012/720185
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发表时间：
2012
影响因子：
2.1
通讯作者：
Sirisha K
中科院分区：
文献类型：
--
作者：
Chava VK;Sirisha K
本文试图总结过去几年中积累的关于黑暗荷尔蒙“褪黑激素”的研究结果。根据它的起源，直到最近，它还被专门描述为一种激素。由于它的亲脂性，它可以被每个细胞接触到。因此，在经典意义上，它是一种细胞保护剂，而不是激素。最近的研究，由Claustrat等人进行。(2005)，检测到松果体外的褪黑素来源很少，如视网膜、胃肠道和唾液腺。由于这些来源，Cutando等人的研究。(2007)，正在试图探索口腔中的褪黑素的含义，除了它在全身水平上的生理抗氧化、免疫调节和抑癌功能，这些功能可能依赖于受体，也可能不依赖于受体。最近，Shimozuma等人的某些体内研究。(2011)，检测到唾液腺分泌褪黑素，进一步强调了其局部活动。因此，在我们的范围内，对褪黑素在口腔中的作用进行了综述，并对褪黑素的系统和口服治疗潜力进行了说明。
This paper attempts to summarise the findings accumulated within the last few years concerning the hormone of darkness “melatonin.” Based on its origin, from the pineal gland until recently it was portrayed exclusively as a hormone. Due to its lipophilic nature, it is accessible to every cell. Thus, in the classic sense it is a cell protector rather than a hormone. Recent studies, by Claustrat et al. (2005), detected few extrapineal sources of melatonin like retina, gastrointestinal tract, and salivary glands. Due to these sources, research by Cutando et al. (2007), is trying to explore the implications of melatonin in the oral cavity, in addition to its physiologic anti-oxidant, immunomodulatory and oncostatic functions at systemic level that may be receptor dependent or independent. Recently, certain in vivo studies by Shimozuma et al. (2011), detected the secretion of melatonin from salivary glands further emphasising its local activity. Thus, within our confines the effects of melatonin in the mouth are reviewed, adding a note on therapeutic potentials of melatonin both systemically and orally.