Nan fiber gorm ation of amphiphilic cyclic tri-β-peptide
Nan fiber gorm ation of amphiphilic cyclic tri-β-peptide
复制标题
两亲性环状三β肽的纳米纤维化
作者：
Y. Ishihara;S. Kimura
合成了一种由两个β -葡萄糖氨基酸和一个反式- 2 -氨基环己基羧酸组成的新型两亲性环肽，并对其组装形成进行了研究。根据制备条件，环三β肽可自组装成棒状晶体或纳米纤维。经电子衍射分析，棒状晶体沿长轴的层间距为4.8 Å，沿短轴的柱状晶体间距为10.8和21.5 Å。前者证实了分子堆积时的柱状结构，后者表明柱状组合形成三束。傅里叶变换红外（FT - IR）测量表明，酰胺基团之间形成了均匀的氢键，也支持环β肽的分子堆叠。获得了直径均匀的直型纳米纤维。版权所有©2010欧洲多肽协会和约翰威利父子有限公司
A novel amphiphilic cyclic peptide composed of two β‐glucosamino acids and onetrans‐2‐aminocyclohexylcarboxylic acid was synthesized and investigated on assembly formation. The cyclic tri‐β‐peptide was self‐assembled into rodlike crystals or nanofibers depending on preparative conditions. The rodlike crystals showed a layer spacing of 4.8 Å along the long axis, and columnar spacings of 10.8 and 21.5 Å by electron diffraction analysis along the short axis. The former confirms the columnar structure upon molecular stacking, and the latter indicates triple bundle formation of the columnar assemblies. Fourier transform infrared (FT‐IR) measurement of the fibrous assembly showed formation of homogeneous hydrogen bonds among amide groups, also supporting the molecular stacking of cyclic β‐peptides. Straight nanofibers with uniform diameter were also uniquely obtained. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.