Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates
Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates
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DOI：
10.1016/j.mencom.2020.03.009
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发表时间：
2020-03-01
影响因子：
1.9
通讯作者：
Fedorov, Alexey Yu.
中科院分区：
文献类型：
--
作者：
Kuzmina, Natalia S.;Otvagin, Vasilii F.;Fedorov, Alexey Yu.
二氢卟酚e（6）衍生物-锌配合物与β-d-半乳糖或β-d-葡萄糖的水溶性偶联物已被合成，作为光动力治疗癌症的潜在药物。它们在低微摩尔浓度下表现出光诱导的细胞毒性，IC 50（暗）/IC 50（光）比接近50。
New water soluble conjugates of chlorin e(6) derivative-zinc complex with beta-d-galactose or beta-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of similar to 50.