Noninvasive transcranial focal stimulation via tripolar concentric ring electrodes lessens behavioral seizure activity of recurrent pentylenetetrazole administrations in rats.
Noninvasive transcranial focal stimulation via tripolar concentric ring electrodes lessens behavioral seizure activity of recurrent pentylenetetrazole administrations in rats.
复制标题
DOI：
10.1109/tnsre.2012.2198244
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Besio WG
中科院分区：
文献类型：
--
作者：
Makeyev O;Luna-Munguía H;Rogel-Salazar G;Liu X;Besio WG
癫痫病影响着世界上大约百分之一的人口。抗癫痫药物在大约30%的患者中无效，并且具有副作用。我们一直在开发一种非侵入性经颅局灶性电刺激与我们的新型三极同心环电极作为替代/补充治疗癫痫发作控制。在这项研究中，我们证明了局灶刺激对大鼠连续两次戊四唑给药引起的行为癫痫发作活动的影响。研究并比较局灶刺激治疗组（n = 9）和对照组（n = 10）的癫痫发作潜伏期、首次行为改变时间、癫痫发作持续时间和最大癫痫发作严重程度评分。首先，我们证明了在第一次戊四唑给药后，没有发现局灶刺激治疗组和对照组的行为活动有显著差异。接下来，比较第一次和第二次戊四唑给药，我们证明了两组中的行为活动（第一次行为变化的时间）发生了显著变化，这与局灶性刺激无关。最后，我们证明了局灶性刺激引起癫痫发作潜伏期，癫痫发作持续时间和最大癫痫发作严重程度评分的显着变化。我们认为，这些结果，结合我们以前的报告，表明经颅局灶刺激可能有抗惊厥作用。
Epilepsy affects approximately one percent of the world population. Antiepileptic drugs are ineffective in approximately 30% of patients and have side effects. We have been developing a noninvasive transcranial focal electrical stimulation with our novel tripolar concentric ring electrodes as an alternative/complementary therapy for seizure control. In this study we demonstrate the effect of focal stimulation on behavioral seizure activity induced by two successive pentylenetetrazole administrations in rats. Seizure onset latency, time of the first behavioral change, duration of seizure, and maximal seizure severity score were studied and compared for focal stimulation treated (n = 9) and control groups (n = 10). First, we demonstrate that no significant difference was found in behavioral activity for focal stimulation treated and control groups after the first pentylenetetrazole administration. Next, comparing first and second pentylenetetrazole administrations, we demonstrate there was a significant change in behavioral activity (time of the first behavioral change) in both groups that was not related to focal stimulation. Finally, we demonstrate focal stimulation provoking a significant change in seizure onset latency, duration of seizure, and maximal seizure severity score. We believe that these results, combined with our previous reports, suggest that transcranial focal stimulation may have an anticonvulsant effect.