Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction
Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction
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DOI：
10.1093/cvr/cvn310
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发表时间：
2009-02-01
影响因子：
10.8
通讯作者：
Stanley, William C.
中科院分区：
文献类型：
--
作者：
Duda, Monika K.;O'Shea, Karen M.;Stanley, William C.
临床研究表明，摄入ω - 3多不饱和脂肪酸（ω - 3 PUFA）可能降低心力衰竭的发生率。膳食补充ω - 3 PUFA具有代谢和抗炎作用，可能预防左心室（LV）病变；然而，尚不清楚这些作用是否在临床相关剂量下发生，以及来自鱼类的ω - 3 PUFA[二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）]与植物来源的[α - 亚麻酸（ALA）]之间是否存在差异。我们评估了在一个涵盖人类服用ω - 3 PUFA补充剂摄入量的剂量范围内，用ω - 3 PUFA治疗的主动脉缩窄大鼠左心室重构和病变的发展情况。大鼠被喂食标准食物或补充有占能量摄入0.7%、2.3%或7%的EPA + DHA或ALA的饮食。在不补充的情况下，主动脉缩窄增加了左心室质量以及收缩末期和舒张末期容积。ALA补充对左心室重构和功能障碍影响很小。相比之下，EPA + DHA呈剂量依赖性地增加EPA和DHA，降低心肌细胞膜磷脂中的花生四烯酸，并防止左心室舒张末期和收缩末期容积的增加。EPA + DHA导致抗炎脂肪因子脂联素呈剂量依赖性增加，并且左心室腔扩大的预防与血浆脂联素水平之间存在强相关性（r = - 0.78）。补充EPA + DHA具有抗聚集和抗炎作用，这可由尿血栓素B - 2和血清肿瘤坏死因子 - α的降低所证明。膳食补充来自鱼类而非植物来源的ω - 3 PUFA，可增加血浆脂联素，抑制炎症，并在压力过载条件下预防心脏重构和功能障碍。
Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with omega-3 PUFA exerts metabolic and anti-inflammatory effects that could prevent left ventricle (LV) pathology; however, it is unclear whether these effects occur at clinically relevant doses and whether there are differences between omega-3 PUFA from fish [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and vegetable sources [alpha-linolenic acid (ALA)].We assessed the development of LV remodelling and pathology in rats subjected to aortic banding treated with omega-3 PUFA over a dose range that spanned the intake of humans taking omega-3 PUFA supplements. Rats were fed a standard food or diets supplemented with EPA+DHA or ALA at 0.7, 2.3, or 7% of energy intake. Without supplementation, aortic banding increased LV mass and end-systolic and -diastolic volumes. ALA supplementation had little effect on LV remodelling and dysfunction. In contrast, EPA+DHA dose-dependently increased EPA and DHA, decreased arachidonic acid in cardiac membrane phospholipids, and prevented the increase in LV end-diastolic and -systolic volumes. EPA+DHA resulted in a dose-dependent increase in the anti-inflammatory adipokine adiponectin, and there was a strong correlation between the prevention of LV chamber enlargement and plasma levels of adiponectin (r = -0.78). Supplementation with EPA+DHA had anti-aggregatory and anti-inflammatory effects as evidenced by decreases in urinary thromboxane B-2 and serum tumour necrosis factor-alpha.Dietary supplementation with omega-3 PUFA derived from fish, but not from vegetable sources, increased plasma adiponectin, suppressed inflammation, and prevented cardiac remodelling and dysfunction under pressure overload conditions.