Multidrug-resistant Gram-negative bacteria: a product of globalization
Multidrug-resistant Gram-negative bacteria: a product of globalization
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DOI：
10.1016/j.jhin.2015.01.008
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发表时间：
2015-04-01
影响因子：
6.9
通讯作者：
Hawkey, P. M.
中科院分区：
文献类型：
--
作者：
Hawkey, P. M.
过去20年来，全球贸易和人员流动迅速增加。这对抗生素抗性基因的进化和运动产生了深远的影响。世界各地的人口越来越多地暴露于新兴经济体产生的耐药细菌。可以说，过去二十年来在抗生素耐药性领域最重要的发展是CTX-M组的超广谱β-内酰胺酶（ESBLs）的出现和传播。亚洲国家肠杆菌科中ESBL产生率非常高的结果是大量使用碳青霉烯类抗生素，导致质粒介导的碳青霉烯类耐药性的出现。本文综述了多重耐药革兰阴性菌的出现和传播，重点介绍了三种特殊的碳青霉烯酶--亚胺培南碳青霉烯酶、肺炎克雷伯菌碳青霉烯酶和新德里金属β-内酰胺酶。并强调了控制抗生素使用的重要性。(C)2015由Elsevier Ltd代表Healthcare Infection Society发布。
Global trade and mobility of people has increased rapidly over the last 20 years. This has had profound consequences for the evolution and the movement of antibiotic resistance genes. There is increasing exposure of populations all around the world to resistant bacteria arising in the emerging economies. Arguably the most important development of the last two decades in the field of antibiotic resistance is the emergence and spread of extended-spectrum beta-lactamases (ESBLs) of the CTX-M group. A consequence of the very high rates of ESBL production among Enterobacteriaceae in Asian countries is that there is a substantial use of carbapenem antibiotics, resulting in the emergence of plasmid-mediated resistance to carbapenems. This article reviews the emergence and spread of multidrug-resistant Gram-negative bacteria, focuses on three particular carbapenemases - imipenem carbapenemases, Klebsiella pneumoniae carbapenemase, and New Delhi metallo-beta-lactamase. and highlights the importance of control of antibiotic use. (C) 2015 Published by Elsevier Ltd on behalf of the Healthcare Infection Society.