Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study
Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study
复制标题
结外自然杀伤/T 细胞淋巴瘤患者治疗后 PET/CT 的预测方法：一项回顾性研究
DOI：
10.1097/mnm.0000000000000731
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发表时间：
2017-11-01
影响因子：
1.5
通讯作者：
Tian, Rong
中科院分区：
文献类型：
--
作者：
Jiang, Chong;Liu, Jie;Tian, Rong
Purpose The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Project (IHP) criteria, the Deauville five-point scale (5-PS), and standardized uptake value (SUV)-based assessment. Patients and methods Fifty-nine patients diagnosed with ENKTL were enrolled. Each patient underwent three 18F-FDG PET/CT scans: (i) baseline, (ii) after two to four cycles of chemotherapy (early response assessment), and (iii) at the end of treatment (evaluation of the final response). Post-therapy 18F-FDG PET/CT results were determined on the basis of IHP criteria, 5-PS, and change in the maximum 18F-FDG uptake (&Dgr;SUVmax). IHP criteria, 5-PS, and &Dgr;SUVmax were then examined for their ability to predict progression-free survival (PFS) and overall survival (OS). Results Over a median follow-up of 25 months, 5-PS and &Dgr;SUVmax were significant predictors of PFS and OS. After multivariate analysis, 5-PS could predict PFS (P=0.008) and OS (P=0.002) independently. &Dgr;SUVmax was found to be an independent predictor of PFS (P=0.019), but not OS, and had a lower accuracy and positive predictive value than 5-PS. Conclusion Post-therapy PET/CT analysis using the 5-PS is more able to predict survival than analysis with IHP or [INCREMENT]SUVmax in ENKTL patients.
