Germ cell sex determination: a collaboration between soma and germline.

Germ cell sex determination: a collaboration between soma and germline.
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DOI:
10.1016/j.ceb.2010.09.006
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发表时间:
2010-12
影响因子:
7.5
通讯作者:
Van Doren M
Van Doren M
中科院分区:
生物学2区
文献类型:
--
作者:
Murray SM;Yang SY;Van Doren M

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性别决定在细胞体和生殖系中的调控方式非常不同,但这两个过程对雄配子和雌配子的产生都是至关重要的。总体而言,体节在调节生殖系的性别认同方面起着至关重要的作用。然而,在一些物种中,如果蝇和小鼠,生殖细胞的性染色体构成对生殖系的性发育具有自主的贡献。在这里,我们回顾了细胞体和生殖系如何合作来确定一些重要的模式系统,苍蝇,蠕虫和老鼠的生殖系性别身份,并讨论了与种系性别仅由周围的细胞体决定的物种相比,“双重控制”(细胞体加生殖系)的一些含义。
Sex determination is regulated very differently in the soma vs. the germline, yet both processes are critical for the creation of the male and female gametes. In general, the soma plays an essential role in regulating sexual identity of the germline. However, in some species, such as Drosophila and mouse, the sex chromosome constitution of the germ cells makes an autonomous contribution to germline sexual development. Here we review how the soma and germline cooperate to determine germline sexual identity for some important model systems, the fly, the worm and the mouse, and discuss some of the implications of “dual control” (soma plus germline) as compared to species where germline sex is dictated only by the surrounding soma.
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