Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone
Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone
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DOI：
10.1159/000239478
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发表时间：
1996-11-01
期刊：
影响因子：
3.3
通讯作者：
Chattopadhyay, U
中科院分区：
文献类型：
--
作者：
Guha, S;Ghosal, S;Chattopadhyay, U
芒果苷是一种从植物中纯化的C-葡糖基吨酮（1，3，6，7-四羟基吨酮-C2-β-D-葡萄糖苷），在瑞士小鼠中显示出对腹水纤维肉瘤具有体内生长抑制活性。在体内或体外治疗后，它还增强了正常和荷瘤小鼠脾细胞和腹腔巨噬细胞的肿瘤细胞毒性。用芒果苷体外处理荷瘤小鼠的脾细胞，导致对自然杀伤细胞既有抗性又有敏感性的肿瘤细胞的杀伤增强。芒果苷也被发现在体外拮抗HIV的细胞病变效应。该药物似乎是一种有效的生物反应调节剂，具有抗肿瘤和抗病毒作用。
Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside) purified from plant sources was shown to have in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Following in vivo or in vitro treatment, it also enhanced tumor cell cytotoxicity of the splenic cells and peritoneal macrophages of normal and tumor-bearing mice. In vitro treatment of the splenic cells of tumor-bearing mice with mangiferin resulted in augmented killing of tumor cells, both resistant and sensitive to natural killer cells. Mangiferin was also found to antagonize in vitro the cytopathic effect of HIV. The drug appears to act as a potent biological response modifier with antitumor and antiviral effect.