Changes in the alpha(2)-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain
Changes in the alpha(2)-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain
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DOI：
10.1097/00001756-199709290-00022
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发表时间：
1997-09-29
期刊：
影响因子：
1.7
通讯作者：
Kim, KJ
中科院分区：
文献类型：
--
作者：
Cho, HJ;Kim, DS;Kim, KJ
我们检测了在大鼠(脊神经结扎)神经病理性疼痛模型中背根神经节(DRG)中编码α(2)-AR亚型基因表达的变化。结果表明，非手术动物背根神经节神经元大部分表达α(2)C-AR mRNA，少数神经元表达α(2)A-AR mRNA，而非手术动物的神经元表达α(2)B-AR mRNA。此外，结扎动物背根神经节中的α(2)C-和α(2)AmRNA水平分别显著降低和升高。这些发现表明，DRG中的α(2)A-和α(2)C-AR可能在产生交感神经维持性神经病理性疼痛中起重要作用。
We examined changes in expression of genes coding for alpha(2)-AR subtypes in the dorsal root gan on (DRG) in rat model (spinal nerve ligation) neuropathic pain. The present study demonstrates that the majority of DRG neurons express alpha(2)C-AR mRNA and a small proportion of neurons express alpha(2)A-AR mRNA, while neurons express alpha(2)B-AR mRNA in non-operated animals. In addition, alpha(2)C- and alpha(2)A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that alpha(2)A- and alpha(2)C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.