An electrolyte-based solution that increases corneal glycogen and conjunctival goblet-cell density in a rabbit model for keratoconjunctivitis sicca.
An electrolyte-based solution that increases corneal glycogen and conjunctival goblet-cell density in a rabbit model for keratoconjunctivitis sicca.
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DOI：
10.1016/s0161-6420(92)31929-3
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发表时间：
1992-04
期刊：
影响因子：
13.7
通讯作者：
J. P. Gilbard;S. R. Rossi
中科院分区：
文献类型：
--
作者：
J. P. Gilbard;S. R. Rossi
32只患单眼手术诱导的干燥性角结膜炎（KCS）的家兔接受了12周的4种人工泪液中的一种的掩蔽治疗。将每组治疗兔的疾病与未治疗KCS对照组的疾病进行比较。测试的溶液之一是一种独特的基于电解质的配方，以前显示在正常家兔中延长暴露后可保持正常杯状细胞密度。治疗9周后，只有电解质溶液降低了泪液渗透压和钠的升高（P <0.05）。在20周时，用电解质基溶液处理的眼睛的平均角膜糖原和结膜杯状细胞密度相对于未处理的KCS对照组显著增加（P <0.01）。对于其他三种溶液，平均糖原水平和杯状细胞密度相对于未处理的KCS对照组降低（P <0.05）或保持不变。基于电解质的溶液是在KCS兔模型中增加角膜糖原和结膜杯状细胞的第一种治疗。
Thirty-two rabbits with monocular surgically induced keratoconjunctivitis sicca (KCS) underwent masked treatment for 12 weeks with 1 of 4 artificial tear solutions. Disease in each group of treated rabbits was compared with disease in untreated KCS controls. One of the solutions tested was a unique electrolyte-based formulation shown previously to preserve normal goblet-cell density after extended exposure in normal rabbits. Only the electrolyte-based solution decreased elevated tear osmolarity and sodium after 9 weeks of treatment (P< 0.05). At 20 weeks, mean corneal glycogen and conjunctival goblet-cell density in eyes treated with the electrolyte-based solution increased significantly relative to untreated KCS controls (P< 0.01). With the other three solutions, mean glycogen levels and goblet-cell densities were either decreased relative to untreated KCS controls (P< 0.05) or were unchanged. The electrolyte-based solution is the first treatment to increase corneal glycogen and conjunctival goblet cells in a rabbit model of KCS.