The Value of 31P NMR in the Diagnosis and Monitoring the Course of Human Myopathies a
The Value of 31P NMR in the Diagnosis and Monitoring the Course of Human Myopathies a
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31P NMR 在诊断和监测人类肌病病程中的价值
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
B. Chance
中科院分区：
文献类型：
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作者：
W. Bank;Z. Argov;J. Leigh;B. Chance
事实证明，核磁共振是人体肌肉生物能量学在健康和疾病方面的一种有价值的研究工具。在过去的五年里，我们评估了它在诊断和监测肌病的病程和治疗方面的实际应用。在线粒体肌病(MM)中首次发现静息状态下异常低的Pcr/P(通常是由于高Pi所致)，这表明磷酸化潜能降低。肌肉营养不良和多发性肌炎)，晚期萎缩性疾病，以及急性肌肉损伤后。在所有这些情况下都可能存在继发性线粒体损伤，这反映了患病肌肉细胞的最终共同途径。尽管这一发现不是疾病特异性的，但它在以下情况下被证明是有用的：(1)监测获得性肌肉疾病。在多发性肌炎PCR/P中，从
"P NMR proved to be a valuable research tool of human muscle bioenergetics in health' and disease.' Over the past five years, we have assessed its practical use in diagnosis and monitoring the course and therapy of myopathies. Abnormally low PCr/P, at rest (usually due to high Pi) was first observed in mitochondrial myopathies (MM)'-' indicating a reduced phosphorylation potentiaL6 Although 13 of 16 of M M patients showed this abn~rmal i ty ,~ a low PCr/P, a t rest was also noted in several destructive myopathies (eg. muscle dystrophy and polymyositis), in advanced atrophic disorders, and following acute muscle injury.? Secondary mitochondrial damage may exist in all these conditions, reflecting a final common pathway in diseased muscle cells. Although this finding is not disease specific, it proved useful in the following situations: ( 1 ) Monitoring acquired muscle disease. In polymyositis PCr/P, fell from