Improved survival and chemotherapy response among patients with AIDS-related non-Hodgkin's lymphoma receiving highly active antiretroviral therapy.
Improved survival and chemotherapy response among patients with AIDS-related non-Hodgkin's lymphoma receiving highly active antiretroviral therapy.
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接受高效抗逆转录病毒治疗的艾滋病相关非霍奇金淋巴瘤患者的生存率和化疗反应得到改善。
DOI：
10.1002/hon.778
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发表时间：
2006
影响因子：
3.3
通讯作者：
Anton-Culver,Hoda
中科院分区：
文献类型：
--
作者：
Diamond,Catherine;Taylor,ThomasH;Im,Theresa;Miradi,Mohammed;Anton-Culver,Hoda
高活性抗逆转录病毒疗法（HAART）于1996年在美国上市。使用基于人群的癌症登记处，我们确定了1994-1999年在圣地亚哥或奥兰治县诊断的233例与艾滋病相关的系统性非霍奇金淋巴瘤患者，其中137例是1996-1999年诊断的。我们采用Kaplan - Meier分析比较NHL诊断时或之后接受HAART治疗的患者与未接受治疗的患者的生存率，并采用Cox比例风险模型比较调整生存率。我们使用逻辑回归来确定合并HAART是否改变了化疗完全缓解的概率，并使用Mann-WhitneyU - test来比较化疗期间接受HAART的患者与未接受HAART的患者的化疗周期中位数。在1996-1999年诊断为NHL的患者中，40例（29%）在诊断为NHL时正在接受HAART治疗。未接受HAART治疗的患者中位生存期为3个月，而接受HAART治疗的患者中位生存期为16个月。HAART、化疗、高性能状态和NHL期< IV期与生存率提高相关。同时进行HAART治疗、完成≥6个化疗周期、NHL分期< IV期与化疗完全缓解相关。接受HAART联合化疗的患者化疗周期中位数为5个，而未接受化疗的患者化疗周期中位数为3个。我们的结论是，在NHL诊断后，包括化疗期间，应开始或继续HAART治疗。版权所有©2006约翰威利父子有限公司
Highly active antiretroviral therapy (HAART) became available in the US in 1996. Using the population‐based cancer registry, we identified 233 patients with AIDS‐related systemic NHL diagnosed in San Diego or Orange County in 1994–1999, of whom 137 were diagnosed 1996–1999. We performed Kaplan‐Meier analyses to compare survival between patients who received HAART at NHL diagnosis or thereafter versus untreated patients and Cox proportional hazard models for adjusted survival. We used logistic regression to determine if concomitant HAART changed the probability of complete response to chemotherapy and the Mann–WhitneyU‐test to compare the median number of chemotherapy cycles between patients who received HAART during chemotherapy versus those who did not. Among patients diagnosed with NHL in 1996–1999, 40 (29%) were taking HAART at NHL diagnosis. The median survival was three months among patients who did not receive HAART versus 16 months among HAART‐treated patients. HAART, chemotherapy, high performance status, and NHL stage < IV were associated with improved survival. Concomitant HAART, completion of ≥ 6 chemotherapy cycles, and NHL stage < IV were associated with complete response to chemotherapy. The median number of chemotherapy cycles was five among patients who received HAART concomitant with chemotherapy versus three among untreated patients. We conclude that HAART should be initiated or continued after NHL diagnosis, including during the period of chemotherapy administration. Copyright © 2006 John Wiley & Sons, Ltd.