The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals.
The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals.
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NOSE 研究（用于根除金黄色葡萄球菌的鼻软膏）：一项在 HIV 感染者中每月使用莫匹罗星的随机对照试验。
DOI：
10.1097/qai.0b013e3181ec2a68
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Lowy,FranklinD
中科院分区：
文献类型：
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作者：
Gordon,RachelJ;Chez,Nancy;Jia,Haomiao;Zeller,Barbara;Sobieszczyk,Magda;Brennan,Caitlin;Hisert,KatherineB;Lee,Mei-Ho;Vavagiakis,Peter;Lowy,FranklinD
Background:HIV-positive patients at HELP/PSI, Inc, an in-patient drug rehabilitation center, had a high baseline prevalence of Staphylococcus aureus colonization (49%) and incidence of infection (17%) in a previous year-long study.Methods:A randomized, double-blinded, placebo-controlled study was conducted to determine whether repeated nasal application of mupirocin ointment would decrease the odds of S. aureus nasal colonization in 100 HELP/PSI patients over an 8-month period. A 5-day course of study drug was given monthly, and colonization was assessed at baseline and 1 month after each treatment. S. aureus infection was a secondary outcome.Results:In repeated-measures analysis, mupirocin reduced the odds of monthly S. aureus nasal colonization by 83% compared with placebo [adjusted odds ratio (OR adj)= 0.17; P< 0.0001]. Subjects colonized at study entry had a 91% reduction in subsequent colonization (OR adj= 0.09; P< 0.0001). Mupirocin also suppressed S. aureus colonization in subjects not colonized at baseline (OR adj= 0.23; P= 0.006). There was no difference in infection rates between the mupirocin and placebo groups (hazard ratio= 0.49, P= 0.29).Conclusions:Monthly application of nasal mupirocin significantly decreased S. aureus colonization in HIV patients in residential drug rehabilitation. Monthly mupirocin application has a potential role in long-term care settings or in HIV-positive patients with high rates of S. aureus colonization and infection.
