Effects of pergolide on intravenous cocaine self administration in men and women
Effects of pergolide on intravenous cocaine self administration in men and women
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DOI：
10.1007/s002130050588
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发表时间：
1998-05-01
影响因子：
3.4
通讯作者：
Fischman, MW
中科院分区：
文献类型：
--
作者：
Haney, M;Foltin, RW;Fischman, MW
临床证据表明，D-1/D-2多巴胺受体激动剂培高利特可能有助于维持可卡因戒断。我们在人类静脉注射可卡因的实验室模型中研究了培高利特的作用。12名住院志愿者(7M，5F)，他们报告每周在可卡因上的平均花费为170美元，服用培高利特(0.05毫克，每日2次)8天，并服用安慰剂8天，不同受试者的药物顺序平衡。自我给药过程发生在每种药物维持的最后4天。采用了经修改的七次试验累进比率选择程序(0、8、16、32毫克/70公斤可卡因与5美元)，会议包括：(A)两次样本试验，参与者回答接受当天可用剂量和代币，以及(B)五次选择试验，参与者在可用剂量和代币之间进行选择。在每次试验之后，对所选选项的响应要求增加了400。培高利特的维持1)减少可卡因诱导的增加，包括“高”、“刺激”、“可卡因”效力、街头价值和心率的不良评分，2)增加“我想要可卡因”的评分，以及3)对可卡因自我给药没有影响。在培高利特维持期间使用可卡因的愿望增加，这表明在这个剂量下治疗效果有限，但考虑到可卡因的主观和心血管影响的减弱，有必要研究更大范围的培高利特剂量对可卡因自我给药和主观影响的影响。
Clinical evidence suggests that pergolide, a D-1/D-2 dopamine receptor agonist, may be useful in maintaining cocaine abstinence. We investigated pergolide's effects in a laboratory model of IV cocaine self-administration by humans. Twelve inpatient volunteers (7M, 5F), who reported spending an average of $170/week on cocaine, received pergolide (0.05 mg BID) for 8 days and placebo for 8 days, with drug order balanced across subjects. Self-administration sessions occurred on the last 4 days of maintenance on each medication. A modified seven-trial progressive ratio choice procedure (0, 8, 16, 32 mg/70 kg cocaine versus $5) was utilized, with sessions consisting of: (a) two sample trials, where participants responded to receive the dose and tokens available that day, and (b) five choice trials, where participants chose between the available dose and tokens. Following each trial, the response requirement for the chosen option increased by 400. Maintenance on pergolide 1) decreased cocaine-induced increases ill ratings of "High," "Stimulated," cocaine "Potency," estimates of street value, and heart rate, 2) increased ratings of "I want cocaine," and 3) had no effect on cocaine self-administration. The increased desire to use cocaine during pergolide maintenance suggests that it has limited treatment utility at this dose, but given the attenuation of cocaine's subjective and cardiovascular effects, an investigation of a wider range of pergolide doses on cocaine self-administration and subjective effects is warranted.