Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802
Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802
复制标题
来自海洋来源的高阳链霉菌 SCSIO 5802 的阿比索星单体和二聚体
DOI：
10.1021/acs.jnatprod.8b00448
复制
发表时间：
2018-08-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Huang, Hongbo;Song, Yongxiang;Ju, Jianhua
从海洋来源的高洋链霉菌SCSIO 5802中发现了3个新的新阿比索菌素单体D(1)、E(2)、A2(3)和2个二聚体新阿比索菌素F(4)和G(5)，并对它们的结构进行了严格的鉴定。Neoabyssomicin D(1)具有前所未有的8/5/5/7环骨架，本文提出对其进行生物合成（以及2）。此外，二聚体制剂4和5分别对耐甲氧西林金黄色葡萄球菌和水疱性口炎病毒有活性。
Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3) and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine-derived Streptomyces koyangensis SCSIO 5802, and their structures rigorously elucidated. Neoabyssomicin D (1) possesses an unprecedented 8/5/5/7 ring skeleton, the biosynthesis of which (as well as 2) is proposed herein. Additionally, dimeric agents 4 and 5 were found to be active against methicillin-resistant Staphylococcus aureus and vesicular stomatitis virus, respectively.