Effects of antipsychotic treatment on membrane phospholipid metabolism in schizophrenia
Effects of antipsychotic treatment on membrane phospholipid metabolism in schizophrenia
复制标题
抗精神病药物治疗对精神分裂症膜磷脂代谢的影响
DOI：
10.1007/s007020170026
复制
发表时间：
2001
影响因子：
3.3
通讯作者：
Wagner F. Gattaz
中科院分区：
文献类型：
--
作者：
A. Schmitt;A. Maras;Georg Petroianu;Dieter F. Braus;L. Scheuer;Wagner F. Gattaz
几项研究表明，精神分裂症患者的脑和血细胞膜磷脂周转增加。然而，这些发现对精神分裂症的特异性和长期抗精神病药物治疗的影响尚未得到证实。在本研究中，我们测量了67例无抗精神病药物的精神分裂症患者血小板膜磷脂浓度，与健康和精神对照组相比，随后在6个月的抗精神病药物治疗期间重复测量。在基线时，与健康人和精神对照组相比，精神分裂症患者的主要磷脂成分磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）水平降低，溶血磷脂酰胆碱（LPC）（磷脂代谢的主要分解产物）水平升高，这表明精神分裂症的发现具有特异性。在抗精神病药物治疗的前3周期间，LPC水平降低至对照值，但在随后的6个月期间再次升高，在此期间结束时达到显著高于对照的水平。因此，至少在外周细胞中，精神分裂症中磷脂的分解增加似乎存在于急性发作期间，仅受初始抗精神病药物治疗的影响，但没有证据表明对膜代谢的长期持续治疗效果。
Several studies have shown an increased membrane phospholipid turnover in brain and blood cells of schizophrenic patients. However the specificity of these findings for schizophrenia and the effects of longterm antipsychotic treatment had yet to be demonstrated. In the present study we measured the concentrations of phospholipids in platelet membranes from 67 neuroleptic-free schizophrenic patients compared to both healthy and psychiatric controls, followed by repeated measurements during a 6 months antipsychotic treatment period. At baseline, levels of the main phospholipid components phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were decreased and lysophosphatidylcholine (LPC), a major breakdown product of phospholipid metabolism, was increased in schizophrenic patients compared to healthy and to psychiatric controls, suggesting a specificity of the findings for schizophrenia. During the first 3-weeks on antipsychotic drug treatment LPC levels decreased to control values, but increased again during the following 6 months, reaching significantly higher levels than controls at the end of this period. Thus, at least in peripheral cells an increased breakdown of phospholipids in schizophrenia appears to be present during the acute episode, being influenced only by initial antipsychotic treatment, but without evidence of a long lasting treatment effect on membrane metabolism.
通过磷磁共振波谱对精神分裂症患者不同疾病阶段的前额皮质进行体内研究。
影响因子：
--
作者：
Stanley,JA;Williamson,PC;Drost,DJ;Carr,TJ;Rylett,RJ;Malla,A;Thompson,RT
通讯作者：
Thompson,RT