DERIVATION AND PROPERTIES OF A BRIEF HEALTH-STATUS ASSESSMENT INSTRUMENT FOR USE IN HIV DISEASE
DERIVATION AND PROPERTIES OF A BRIEF HEALTH-STATUS ASSESSMENT INSTRUMENT FOR USE IN HIV DISEASE
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DOI：
10.1097/00042560-199503010-00006
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发表时间：
1995-03-01
期刊：
影响因子：
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通讯作者：
WU, AW
中科院分区：
文献类型：
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作者：
BOZZETTE, SA;HAYS, RD;WU, AW
根据医疗结果研究 (MOS) 量表改编的健康状况衡量标准已被证明对人类免疫缺陷病毒感染人群有用且高度可靠，但这些衡量标准的接受程度在一定程度上受到对研究者、患者和数据负担的担忧的限制。我们试图通过减少 MOS 量表中的项目数量而不是减少涵盖的领域数量来解决这些问题。我们根据来自 1,934 名参与者以及相关亚群的 10,399 份回复中与较长量表以及临床和功能状态指标的静态和动态关系，选择了较短量表的项目。最终的量表共有 21 个项目，而较长的仪器则有 38 个项目。较短和较长尺度之间的相关性非常好。在0.78至0.85之间，子量表的信度低于满量表的信度。然而，与基于较长量表的指数相比，基于子量表的指数具有相同的可靠性，产生几乎相同的值，并且在检测临床试验中的治疗差异方面同样敏感。由此产生的工具继续涵盖残疾、工作、利用率和健康状况，但长度不到我们之前综合调查问卷的一半。
Health status measures adapted from the Medical Outcomes Study (MOS) scales have been shown to be useful and highly reliable in human immunodeficiency virus-infected populations, but acceptance of these measures has been limited in part by concerns over investigator, patient, and data burden. We sought to address these concerns by reducing the number of items in the MOS scales rather than by reducing the number of domains covered. We selected items for the shorter scales based on the static and dynamic relationships to the longer scales and to indicators of clinical and functional status in 10,399 responses from 1,934 participants, as well as in relevant subpopulations. The resulting scales have a total of 21 items, as compared to 38 in the longer instrument. Correlations between the shorter and longer scales were excellent. At 0.78 to 0.85, the reliability of the subscales was lower than that of the full scales. However, compared to an index based on the longer scales, an index based on the subscales had identical reliability, yielded nearly identical values, and was as sensitive in detecting treatment differences in a clinical trial. The resulting instrument continues to cover disability, work, utilization, and health status, but is less than half the length of our previous comprehensive questionnaires.